Integrated magnetic probes for neuronal current imaging

低频磁场通过生物组织时不会产生明显的变形，因此能够与生物系统内的设备进行有效的远程交互。在此之前，我们已经实现了第一个实验证明的概念，本地记录的活动，在体内的神经网络与一种新型的工具，基于自旋电子。为了实现神经元级的单事件记录，我们需要提高传感器的灵敏度，并将电子器件与传感器共同集成，以改善形状因子和信号完整性。为了实现这一目标，在拟议的NeuroTMR项目中，我们将使用我们的低噪声隧道磁阻传感器，并将所有相关电子设备直接集成到探头上。由此产生的新工具将打开磁生理学领域，通过实现神经元中离子流的映射来了解神经元信息传输的机制，包括矢量信息和多神经元同时记录，为持久的植入物铺平道路，可能用于脑机接口。

Low-frequency magnetic fields pass through biological tissues without significant distortion, thus enabling efficient, remote interaction with devices inside a biological system. Previously, we have realized the first experimental proof of concept of locally recording the activity of neuronal networks in vivo with a new type of tool based on spin electronics. To realize single-event recordings at neuron scale, we need to improve the sensor sensitivity and to co-integrate the electronics with the sensor for an improved form factor and signal integrity. To achieve this, in the proposed project NeuroTMR, we will use our low-noise Tunnel Magneto Resistance sensors and incorporate all relevant electronics directly onto the probe. The resulting new tool will open the field of magnetophysiology to understand the mechanisms of neuronal information transmission by realizing a mapping of the ionic flows in the neuropil, including vectorial information and multi-neurons simultaneous recordings, paving the way for durable implants, possibly for brain-machine interface.