课题基金 / 基金详情

Modelling DNA methylation in the systemic progression of cancer

Modelling DNA methylation in the systemic progression of cancer
癌症全身进展中的 DNA 甲基化建模
批准号:
392961754
负责人:
Professor Dr. Michael Rehli
金额:
$0.0万
依托单位国家:
德国
项目类别:
Research Units
财政年份:
2017
资助国家:
德国
项目状态:
已结题
起止时间:
2016-12-31 至 2021-12-31

项目摘要

项目成果

Professor Dr. Michael Rehli的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
DNA methylation is a heritable epigenetic mechanism that is frequently altered in cancer and that shows significant intratumoural heterogeneity. It also integrates transcriptional and metabolic signals, and may thus stabilize/support metastatic transcriptional programs complementing the effects of genetic alterations. The BalbNeuT mouse model studied by our consortium lacks genetic evidence for metastatic driver mutations. However, it shows marked epigenetic differences between primary tumours and metastasis. It is therefore ideally suited to model methylation progression addressing key questions regarding the impact of epigenetic alterations on metastatic progression. In the first funding period the projects A2 (Spang) and A4 (Rehli) collaborated intensively to study methylation progression in the context of the BalbNeuT mouse model. We have monitored DNA methylation during systemic progression, have identified multiple distinct patterns of methylation progression, and have developed a new type of dynamic cross sectional models that allows for the joint analysis of methylation timing and the causal relations between methylation and dissemination.Joining forces and building on these results, we now propose to develop a novel type of epigenetic progression models, that include early lesions in addition to full grown primary tumours and lung metastasis, fine tune them on a representative set of 25 promoter regions that recurrently show methylation progression, and validate the model using CRISPR/Cas9 mediated gene silencing assays. Moreover, we will use longitudinal liquid biopsies to search for progressed methylation early in systemic progression.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Differentiation-associated, macrophage-specific gene expression: Mechanisms of transcription regulation
Mechanism and relevance of active DNA methylation during monocyte differentiation
Evolution of genetic & epigenetic aberrations during malignant progression of breast cancerand the impact of the local environment
Strain specific DNA methylation in inbred mice: mechanisms of cis- and trans-regulation during development
国内基金
海外基金
PCV2茎环结构DNA激活cGAS-STING通路诱导的天然免疫应答的作用研究
  • 批准号:
    2026JJ50413
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2026
  • 负责人:
    王东亮
  • 依托单位:
机械力响应型DNA探针用于肿瘤微环境细胞力学可视化与药物筛选研究
  • 批准号:
    2026JJ60135
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2026
  • 负责人:
    杨思慧
  • 依托单位:
CDC45通过调控DNA复制应激促进肝癌发生发展的机制
自供能传感阵列同步量化游离DNA与PSA实现前列腺癌的诊断和预后判断
  • 批准号:
    JCZRLH202601177
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2026
  • 负责人:
  • 依托单位: