Investigation of mechanism of bone metastasis and the novel treatment of metastatic bone tumor

骨转移机制研究及转移性骨肿瘤治疗新方法

• 批准号: 16K15658
• 负责人: Tsuchiya Hiroyuki
• 金额: $ 2.16万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2016
• 资助国家: 日本
• 起止时间: 2016-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16K15658/
• 关键词: 骨転移; 蛍光タンパク; 腫瘍切除術; 蛍光イメージング; 蛍光ガイド下手術; がん; 癌; 骨髄; 蛍光蛋白; 転移

项目成果

Temozolomide combined with irinotecan regresses a cisplatinum-resistant relapsed osteosarcoma in a patient-derived orthotopic xenograft (PDOX) precision-oncology mouse model.

• DOI: 10.18632/oncotarget.22892
• 发表时间: 2018-01-30
• 期刊: Oncotarget
• 作者: Igarashi K;Kawaguchi K;Kiyuna T;Miyake K;Miyake M;Li Y;Nelson SD;Dry SM;Singh AS;Elliott IA;Russell TA;Eckardt MA;Yamamoto N;Hayashi K;Kimura H;Miwa S;Tsuchiya H;Eilber FC;Hoffman RM
• 通讯作者: Hoffman RM

Efficacy of glycogen synthase kinase-3β targeting against osteosarcoma via activation of β-catenin.

• DOI: 10.18632/oncotarget.12781
• 发表时间: 2016-11-22
• 期刊: Oncotarget
• 作者: Shimozaki S;Yamamoto N;Domoto T;Nishida H;Hayashi K;Kimura H;Takeuchi A;Miwa S;Igarashi K;Kato T;Aoki Y;Higuchi T;Hirose M;Hoffman RM;Minamoto T;Tsuchiya H
• 通讯作者: Tsuchiya H

Reliability of radiographic evaluations of the stage of osteoarthritis of the hip joint and an approach to improve the staging criteria

髋关节骨关节炎分期放射学评估的可靠性以及改进分期标准的方法

• DOI: 10.1016/j.jos.2017.05.007
• 发表时间: 2017
• 期刊: J Orthop Sci
• 影响因子: 1.7
• 作者: Yoshitani Junya;Nakamura Takuya;Ueshima Kenichi;Ebara Hidehumi;Kabata Tamon;Tsuchiya Hiroyuki
• 通讯作者: Tsuchiya Hiroyuki

Selection of a Surgical Approach for Total Hip Arthroplasty According to the Depth to the Surgical Site

根据手术部位深度选择全髋关节置换手术入路

• DOI: 10.5301/hipint.5000463
• 发表时间: 2017
• 期刊: Hip Int
• 影响因子: 1.5
• 作者: Ohmori Takaaki;Kabata Tamon;Maeda Toru;Kajino Yoshitomo;Taga Tadashi;Hasegawa Kazuhiro;Inoue Daisuke;Yamamoto Takashi;Takagi Tomoharu;Tsuchiya Hiroyuki
• 通讯作者: Tsuchiya Hiroyuki

Efficacy of the Combination of a PARP Inhibitor and UVC on Cancer Cells as Imaged by Focus Formation by the DNA Repair-related Protein 53BP1 Linked to Green Fluorescent Protein

PARP 抑制剂和 UVC 组合对癌细胞的功效，通过与绿色荧光蛋白连接的 DNA 修复相关蛋白 53BP1 形成焦点进行成像

• 发表时间: 2016
• 期刊: Anticancer Res
• 影响因子: 2
• 作者: Tome Y;Uehara F;Miwa S;Yano S;Mii S;Efimova EV;Bouvet M;Kimura H;Tsuchiya H;Kanaya F;Hoffman RM
• 通讯作者: Hoffman RM