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Elucidation of roles of gasotransmitters in the pathogenesis of atopic dermatitis

阐明气体递质在特应性皮炎发病机制中的作用

基本信息

批准号：
18F18410
负责人：
高森建二
金额：
$ 1.47万
依托单位：
Juntendo University
依托单位国家：
日本
项目类别：
Grant-in-Aid for JSPS Fellows
财政年份：
2018
资助国家：
日本
起止时间：
2018-10-12 至 2021-03-31
项目状态：
已结题

项目摘要

Despite the numerous reports that H2S is involved in various pathological diseases and/or itch, however, there have been no reports of its involvement in the expression of axon-guidance molecules in human keratinocytes (KCs).I found that H2S-producing enzymes were expressed in human skin (mainly KCs), and were increased in human atopic dermatitis (AD) skin lesion. Notably, the H2S donor stimulation upregulated NGF and ARTN, and downregulated Sema3A levels in the cultured normal human epidermal keratinocytes, which is considered to be a cause of peripheral itch sensitization in AD skin lesion. I suggest that the involvement of H2S under the experimental conditions used in the present work in relation with AD. Our data raise the possibility that H2S, at least in part, modulates the epidermal hyperinnervation of the human skin through alteration of axon-guidance molecules in KCs. These findings add insight of the possible role of gasotransmitter in epidermal hyperinnervation of human skin, especially in itchy skin inflammatory condition such as AD. The result of the project has been published in international journal (Journal of Dermatological Science).

尽管H2S参与了多种病理性疾病和/或瘙痒的研究，但还没有H2S参与角质形成细胞（KC）轴突导向分子表达的报道。值得注意的是，H2S供体刺激上调了培养的正常人表皮角质形成细胞中的NGF和ARTN，并下调了Sema 3A水平，这被认为是AD皮肤病变中外周瘙痒致敏的原因。我建议在本工作中使用的实验条件下，H2S的参与与AD有关。我们的数据提高了H2S，至少在一定程度上，通过改变KC中的轴突导向分子来调节人类皮肤的表皮神经支配的可能性。这些发现增加了对气体递质在人类皮肤的表皮神经过度支配中的可能作用的了解，特别是在瘙痒的皮肤炎症状态如AD中。该项目的成果已发表在国际期刊（皮肤科学杂志）上。

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Relationships among β-endorphin, dynorphin A, and pruritus in patients with chronic liver diseases

β-内啡肽、强啡肽A与慢性肝病患者瘙痒的关系

DOI：
发表时间：
2018
期刊：
影响因子：
0
作者：
Azela Gladya;Manami Tanaka,;Catharina Sagita Moniaga;Masato Yasui、Mariko Hara-Chikuma;Catharina Sagita Moniaga
通讯作者：
Catharina Sagita Moniaga

Hydrogen sulfide modulates the expression of axon-guidance molecules in human keratinocytes.