Elucidation of roles of gasotransmitters in the pathogenesis of atopic dermatitis

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Despite the numerous reports that H2S is involved in various pathological diseases and/or itch, however, there have been no reports of its involvement in the expression of axon-guidance molecules in human keratinocytes (KCs).I found that H2S-producing enzymes were expressed in human skin (mainly KCs), and were increased in human atopic dermatitis (AD) skin lesion. Notably, the H2S donor stimulation upregulated NGF and ARTN, and downregulated Sema3A levels in the cultured normal human epidermal keratinocytes, which is considered to be a cause of peripheral itch sensitization in AD skin lesion. I suggest that the involvement of H2S under the experimental conditions used in the present work in relation with AD. Our data raise the possibility that H2S, at least in part, modulates the epidermal hyperinnervation of the human skin through alteration of axon-guidance molecules in KCs. These findings add insight of the possible role of gasotransmitter in epidermal hyperinnervation of human skin, especially in itchy skin inflammatory condition such as AD. The result of the project has been published in international journal (Journal of Dermatological Science).