Membrane and synaptic properties of neurons that are involved in the velocity-position transformation in the vertical eye movement system

垂直眼动系统中参与速度-位置变换的神经元的膜和突触特性

• 批准号: 24650160
• 负责人: SAITO Yasuhiko
• 金额: $ 2.5万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24650160/
• 关键词: 神経生理学; 視線制御; 神経積分器; パッチクランプ法; 眼球運動; パッチクランプ

To characterize neurons in the interstitial nucleus of Cajal (INC) that is involved in controlling vertical gaze, we investigated the electrophysiological properties such as firing pattern of INC neurons using whole-cell recordings in rat slice preparations. Furthermore, we compared the findings obtained from INC neurons to those previously obtained from neurons in the prepositus hypoglossi nucleus that is involved in controlling horizontal gaze. We found that the electrophysiological properties of INC neurons were similar to those of PHN neurons; however, the overall distribution of INC neurons that were classified based on the properties was different from that of PHN neurons. These findings suggest that the neuronal population involved in the gaze control is different between the horizontal and vertical system.

为了表征Cajal间质核（INC）中参与控制垂直凝视的神经元，我们在大鼠切片制备中使用全细胞记录研究了INC神经元的电生理特性，如放电模式。此外，我们将从INC神经元获得的结果与先前从参与控制水平凝视的前置点舌下核神经元获得的结果进行了比较。我们发现INC神经元的电生理特性与PHN神经元相似；然而，根据性质分类的INC神经元的总体分布与PHN神经元不同。这些发现表明，参与凝视控制的神经元群在水平和垂直系统中是不同的。

项目成果

Pharmacological analyses of nicotinic current responses in the rat medial vestibular and prepositus hypoglossi cholinergic neurons.

大鼠内侧前庭和舌前舌下胆碱能神经元烟碱电流反应的药理学分析。

• 发表时间: 2013
• 作者: Zhang Y;Yanagawa Y;and Saito Y
• 通讯作者: and Saito Y

The vestibulo- and preposito-cerebellar cholinergic neurons of a ChAT-tdTomato transgenic rat exhibit heterogeneous firing properties and the expression of various neurotransmitter receptors.

ChAT-tdTomato 转基因大鼠的前庭和前小脑胆碱能神经元表现出异质放电特性和各种神经递质受体的表达。

• DOI: 10.1111/ejn.12509
• 发表时间: 2014
• 期刊: Eur J Neurosci.
• 作者: Zhang Y;Kaneko R;Yanagawa Y;Saito Y.
• 通讯作者: Saito Y.

Ca^<2+>-activated ion currents triggered by ryanodine receptor-mediated Ca^<2+> release control the firing of inhibitory neurons in the prepositus hypoglossi nucleus

兰尼碱受体介导的 Ca^2 释放触发的 Ca^2 激活离子流控制舌下核前抑制性神经元的放电

• 发表时间: 2013
• 期刊: Journal of Neurophysiology
• 影响因子: 2.5
• 作者: Shigeki KATO;Ryoji FUKABORI and Kazuto KOBAYASHI;Saito Y and Yanagawa Y
• 通讯作者: Saito Y and Yanagawa Y

Intrinsic membrane properties and nicotinic receptor-mediated current responses of cholinergic neurons in the medial vestibular and prepositus hypoglossi nuclei as analyzed in ChAT-tdTomato transgenic rats.

在 ChAT-tdTomato 转基因大鼠中分析内侧前庭和前位舌下核中胆碱能神经元的内在膜特性和烟碱受体介导的电流反应。

• 发表时间: 2013
• 作者: Zhang Y;Kaneko R;Yanagawa Y;and Saito Y
• 通讯作者: and Saito Y