Development of the new treatment for the muscle injury using ultrasonic stimulation

利用超声波刺激治疗肌肉损伤的新疗法的开发

• 批准号: 24650337
• 负责人: MIYAMOTO Yasunori
• 金额: $ 2.16万
• 依托单位: Chubu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24650337/
• 关键词: リハビリテーション; 発生・分化; ラット; 細胞・組織; 理学療法学; 筋損傷

This research verified ultrasonic stimulation can promote recovery from muscle damage. We produced the model of injured rats is caused by eccentric contraction of anterior tibial muscle. The anterior tibial muscle was pulsed 10 minutes by ultrasonic stimulation. Functional evaluation, histological evaluation, and biochemical evaluation were used for evaluation of recovery from muscle damage.As a result, ultrasonic stimulation added 2 hours after eccentric contraction is effective in promoting recovery from injury. Moreover, the expression level of MyoD and Myogenin protein which are an active index of a satellite cell increases by ultrasonic stimulation. The examination suggested that an ultrasonic stimulus becomes a new treatment for the promotion of recovery from muscle damage.

这项研究证实了超声波刺激可以促进肌肉损伤的恢复。建立大鼠胫前肌离心性收缩损伤模型。通过超声刺激对胫前肌进行脉冲10分钟。通过功能评价、组织学评价和生化评价对肌肉损伤的恢复进行评价，结果表明，离心收缩后2小时加用超声波刺激对促进损伤的恢复有效。此外，作为卫星细胞的活性指标的MyoD和Myogenin蛋白的表达水平通过超声刺激而增加。研究表明，超声波刺激成为促进肌肉损伤恢复的新疗法。

项目成果

超音波刺激が筋損傷の回復過程に与える影響

超声刺激对肌肉损伤恢复过程的影响

• 发表时间: 2013
• 作者: 柴田篤志;森友洋;縣信秀;宮本靖義;宮津真寿美;河上敬介
• 通讯作者: 河上敬介