Calorie restriction associated microRNA: Possibility of biomarkers of human aging-dependent diseases

MicroRNAs （miRNAs）属于一个小的非编码RNA家族，调控靶信使RNA （mrna）的翻译过程。据报道，miRNA在体内循环（如循环miRNA， c-miRNA），一些c-miRNA的表达随着生理条件的改变而改变。我们研究了c- mirna在人血浆中的功能及其作为生物标志物的应用。我们通过定量PCR鉴定了与高血压和肥胖相关的c-miRNAs，这表明c-miRNAs可能调节远处器官的代谢状态。因此，血浆中c- mirna的鉴定在诊断和建立生活方式相关疾病的治疗靶点方面具有很高的潜力。

MicroRNAs (miRNAs) belong to a small, non-coding RNA family and regulate the translational process of target messenger RNAs (mRNAs). It is reported that miRNAs circulate throughout a body (as circulating miRNA, c-miRNA), and that some c-miRNA expressions are altered with the physiological condition. We investigated the function of c-miRNAs in human blood plasma and their application as a biomarker. We identified the c-miRNAs associated with hypertension and obesity by using quantitative PCR, which suggested that c-miRNAs might regulate the metabolic state among distant organs. Thus, the identification of c-miRNAs in blood plasma has a high potential use both for diagnosis and for establishing a therapeutic target among lifestyle-related diseases.