Molecular mechanisms of acinar cell injury in acute pancreatitis

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STAT3 is a transcription factor which controls several gene expression levels associated with cell proliferation, inflammation, and cell survival. In the study, we clarified STAT3 played a protective role in pancreatic necrosis, inflammatory cell infiltration and apoptotic cell death using caerulein-administrated conditional STAT3 knockout mice, In the models of caerulein or L-arginine-induced acute pancreatitis, while the expression levels of Bcl-xL and Mcl-1 (anti-apoptotic proteins) increased, the severity of pancreatitis did not worsen in conditional Bcl-xL knockout mice compared with control mice. Collectively, these results suggested that Bcl-xL and Mcl-1may function redundantly in regulation of acute pancreatitis.