Induction of immune-tolerance by a novel human trophoblast-specific soluble factor, laeverin
Induction of immune-tolerance by a novel human trophoblast-specific soluble factor, laeverin
批准号:
24659730
负责人:
FUJIWARA Hiroshi
金额:
$2.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012 至 --
中文摘要
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英文摘要
During human placentation, extravillous trophoblast invades maternal endometrium and remodels spiral arteries. In this study, we examined the physiological roles of a novel human trophoblast-specific soluble factor, laeverin that we identified. We found that soluble-form laeverin induced differentiation of monocytes into dendritic cells and showed possible involvement of laeverin in induction of immune-tolerance in cooperation with HLA-G. These findings provide a new insight into the mechanisms for intrauterine human fetal development.
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Overexpression of TEX101, a potential novel cancer marker, in head and neck squamous cell.
TEX101(一种潜在的新型癌症标记物)在头颈鳞状细胞中过度表达。
DOI:
--
发表时间:
2013
期刊:
Cancer Biomark
影响因子:
3.1
作者:
[Yoshitake H, Yokoi H, Ishikawa H, Maruyama M, Endo S, Nojima M, Yoshida K, Yoshikawa H, Suzuki F, Takamori K, Fujiwara H and Araki Y]
通讯作者:
Fujiwara H and Araki Y
月経時の子宮内膜修復過程において、血小板は子宮内膜上皮のintegrityを増強させる
血小板在月经期间子宫内膜修复过程中增强子宫内膜上皮的完整性
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[杉並 興, 佐藤幸保, 堀江昭史, 松本久宣, 谷 洋彦, 藤原 浩, 小西郁生]
通讯作者:
小西郁生
DOI:
10.1097/igc.0b013e3182849e36
发表时间:
2013-03-01
期刊:
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
影响因子:
4.8
作者:
[Fujiwara, Hiroshi, Nishioka, Yoshihiro, Konishi, Ikuo]
通讯作者:
Konishi, Ikuo
DOI:
10.3233/cbm-130302
发表时间:
2012-01-01
期刊:
CANCER BIOMARKERS
影响因子:
3.1
作者:
[Yoshitake, Hiroshi, Yokoi, Hidenori, Araki, Yoshihiko]
通讯作者:
Araki, Yoshihiko
DOI:
--
发表时间:
2012
期刊:
Reprod Med Biol.
影响因子:
--
作者:
[Sato Y, Fujiwara H and Konishi I]
通讯作者:
Fujiwara H and Konishi I
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