The autoantibody effects of periodontopathic bacteria on threatened preterm labor and preterm birth.

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Periodontal disease is considered to be a risk factor for threatened preterm labor (TPL) and adverse delivery outcomes such as preterm birth and low birth weight (PLBW). Oral plaque and saliva were taken from 28 women diagnosed as TPL; a further 36 control samples were acquired from healthy pregnant women. Placenta samples were taken after delivery. Periodontopathic bacteria were identified by real-time PCR with TaqMan probe. Serum IgG antibodies against periodontopathic bacteria were measured by ELISAOf 64 births, 13 delivered PLBW. Serum anti-P.gingivalis IgG antibody titer, plaque P.gingivalis levels, plaque T.forsythia level and saliva P.intermedia levels were significantly higher in the PLBW group compared with controls. Between TPL and healthy control group, there was no significant difference.This study suggested that oral infection with P.gingivalis, T.forsythia and P.intermedia, and high level of anti-P.gingivalis IgG antibody titer are risk factors in PLBW.