The autoantibody effects of periodontopathic bacteria on threatened preterm labor and preterm birth.

牙周病细菌的自身抗体对先兆早产和早产的影响。

• 批准号: 24659921
• 负责人: IZUMI Yuichi
• 金额: $ 2.41万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659921/
• 关键词: 歯周病; 早産; 早期低体重児; 早期低体重児出産; 切迫早産; 自己抗体; 抗リン脂質抗体

Periodontal disease is considered to be a risk factor for threatened preterm labor (TPL) and adverse delivery outcomes such as preterm birth and low birth weight (PLBW). Oral plaque and saliva were taken from 28 women diagnosed as TPL; a further 36 control samples were acquired from healthy pregnant women. Placenta samples were taken after delivery. Periodontopathic bacteria were identified by real-time PCR with TaqMan probe. Serum IgG antibodies against periodontopathic bacteria were measured by ELISAOf 64 births, 13 delivered PLBW. Serum anti-P.gingivalis IgG antibody titer, plaque P.gingivalis levels, plaque T.forsythia level and saliva P.intermedia levels were significantly higher in the PLBW group compared with controls. Between TPL and healthy control group, there was no significant difference.This study suggested that oral infection with P.gingivalis, T.forsythia and P.intermedia, and high level of anti-P.gingivalis IgG antibody titer are risk factors in PLBW.

牙周病被认为是先兆早产（TPL）和不良分娩结果（例如早产和低出生体重（PLBW））的危险因素。采集了 28 名被诊断为 TPL 的女性的口腔菌斑和唾液；另外 36 个对照样本是从健康孕妇身上采集的。分娩后采集胎盘样本。使用 TaqMan 探针通过实时 PCR 鉴定牙周病细菌。通过 ELISA 测定了 64 名新生儿中 13 名已分娩的 PLBW 的血清 IgG 抗体。与对照组相比，PLBW组的血清抗牙龈卟啉单胞菌IgG抗体滴度、菌斑牙龈卟啉单胞菌水平、菌斑连翘连翘水平和唾液中间卟啉菌水平显着高于对照组。 TPL与健康对照组之间无显着性差异。本研究提示口腔感染P.gingivalis、T.forsythia和P.intermedia以及高水平的抗P.gingivalis IgG抗体滴度是PLBW的危险因素。

项目成果

Periopathogenic bacteria in oral plaque, saliva and placenta from preterm low birth weight cases

早产低出生体重病例口腔菌斑、唾液和胎盘中的周围病原菌

• 发表时间: 2013
• 作者: Ye C;Kobayashi H;Katagiri S;Takeuchi Y;Nagasawa T;Izumi Y
• 通讯作者: Izumi Y

Periopathogenic Bacteria in Oral Plaque

口腔菌斑中的周围致病细菌

• 发表时间: 2013
• 作者: Ye C;Katagiri S;Bharti P;Kobayashi H;Takeuchi Y;Nagasawa T;Izumi Y
• 通讯作者: Izumi Y

切迫早産と低体重児出産における歯周病原細菌とその抗体価に関する研究

先兆早产及低体重儿牙周病原菌及其抗体滴度研究

• 发表时间: 2014
• 作者: 御給美沙;葉 ;片桐 さやか;小林宏明;竹内康雄;南原弘美;須田智也;池田裕一;須藤毅顕;長澤敏行;和泉雄一
• 通讯作者: 和泉雄一

The anti-phospholipid antibody-dependent and independent effects of periodontopathic bacteria on threatened preterm labor and preterm birth

• DOI: 10.1007/s00404-013-2741-z
• 发表时间: 2013-02
• 期刊: Archives of Gynecology and Obstetrics
• 影响因子: 2.6
• 作者: C. Ye;Sayaka Katagiri;N. Miyasaka;Pariksha Bharti;H. Kobayashi;Y. Takeuchi;Yoshihito Momohara;M. Sekiguchi;Satoko Takamine;T. Nagasawa;Y. Izumi

Periopathogenic Bacteria in Oral Plaque, Saliva and Placenta from PLBW

来自 PLBW 的口腔菌斑、唾液和胎盘中的周围致病细菌

• 发表时间: 2013
• 作者: C. YE;H. KOBAYASHI;P. BHARTI;S. KATAGIRI;Y. TAKEUCHI;T. NAGASAWA;and Y. IZUMI
• 通讯作者: and Y. IZUMI