Ion mobility spectrometry coupled to chip-based electrochromatography

离子迁移谱与基于芯片的电色谱耦合

• 批准号: 396430937
• 负责人: Professor Dr. Detlev Belder
• 金额: --
• 依托单位: Institut für Grundlagen der Elektrotechnik und Messtechnik
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/396430937?language=en
• 关键词: Ion; mobility; spectrometry; coupled; chip

The core motivation of the project -Ion mobility spectrometry coupled to chip-based electrochromatography- is the development of a novel analytical tool that enables fast and highly sensitive analysis of complex samples. By fusing electrically driven miniaturized chromatography with ion mobility spectrometry a system combining the desirable features of the two techniques namely high efficiency liquid phase separations and highly sensitive ion detection in the gas phase is to be developed. In contrast to other hyphenated techniques like HPLC/MS, both electrochromatography and ion mobility spectrometry do not require elaborate secondary equipment like pumps which facilitates on-site or portable use of the system. The research focus is on developing of appropriate microfluidic chip interface technology with emphasis on a novel drift tube ion mobility spectrometer with inverted electrical polarity and optional chemical gas phase ionization complementary to electrospray ionization.

该项目的核心动机-离子迁移谱与基于芯片的电色谱耦合-是开发一种新型分析工具，可以快速，高灵敏度地分析复杂样品。通过将电驱动小型化色谱与离子迁移谱相融合，将开发一种结合两种技术的理想特征的系统，即高效液相分离和气相中的高灵敏度离子检测。与其他联用技术如HPLC/MS相比，电色谱和离子迁移谱都不需要复杂的辅助设备，如泵，这有助于现场或便携式使用系统。研究重点是开发合适的微流控芯片接口技术，重点是一种新型的漂移管离子迁移谱仪，具有反转的电极性和可选的化学气相离子化互补电喷雾离子化。

项目成果

IMS Instrumentation I: Isolated data acquisition for ion mobility spectrometers with grounded ion sources

• DOI: 10.1007/s12127-020-00260-5
• 发表时间: 2020-05-07
• 期刊: INTERNATIONAL JOURNAL FOR ION MOBILITY SPECTROMETRY
• 作者: Lippmann, Martin;Kirk, Ansgar T.;Zimmermann, Stefan
• 通讯作者: Zimmermann, Stefan

Wireless Low-Power Transfer for Galvanically Isolated High-Voltage Applications

• DOI: 10.3390/electronics11060923
• 发表时间: 2022-03-01
• 期刊: ELECTRONICS
• 影响因子: 2.9
• 作者: Hitzemann, Moritz;Lippmann, Martin;Zimmermann, Stefan
• 通讯作者: Zimmermann, Stefan

4.2 - Compact Electrospray Ionization Ion Mobility Spectrometer

4 2 - 紧凑型电喷雾电离离子淌度谱仪

• DOI: 10.5162/15dss2021/4.2
• 发表时间: 2021
• 期刊: Vorträge
• 作者: C. Thoben;C.-R. Raddatz;A. Ahrens;J. B. Schulte;A. Staschel;S. Zimmermann
• 通讯作者: S. Zimmermann