Digital microfluidics (DMF) for SERS analysis on a chip with EWOD-/(w)OEW-actuated analyte droplets

使用 EWOD/(w)OEW 驱动的分析物液滴在芯片上进行 SERS 分析的数字微流体 (DMF)

基本信息

项目摘要

Electrically conducting fluid droplets can be actuated via electrowetting on dielectric (EWOD) and opto-electrowetting (OEW). In principle, the OEW control lightwave might even be waveguided within the layer sequence beneath the droplet (idea Fouckhardt, waveguide-based OEW = wOEW). An important application is represented by droplet manipulation in digital microfluidics (DMF, lab on a chip 2.0) in chemical chip-sized laboratories.An obstacle for a break-through of digital microfluidics in miniaturized chemistry is given by a lack of sensitive, non-destructive methods for detection, allowing for the doubtless identification of chemical substances in discrete droplets on a DMF chip. In the project proposed here surface-enhanced Raman scattering or spectroscopy (SERS) shall be employed for this purpose on a chip for the first time (idea Belder), which shall make well evaluable vibrational spectra possible. By the interaction of the analyte molecules (within the droplets) e. g. with metallic nanoparticles dispersed in the droplets high signal amplifications should be obtainable.The undertaking is aimed at the first-time combination of DMF and SERS and the concurrent droplet actuation by EWOD-OEW-wOEW. By the optical initiation of the droplet movement new opportunities for the realization of unpretentious lab on a chip systems should arise.The cooperation of the groups Belder and Fouckhardt should provide for synergies, which make a break-through of the DMF technology in the context of chemical lab-chips possible. The Belder group focuses on SERS detection within DMF systems. The Fouckhardt group concentrates on further development of droplet actuation via EWOD and OEW, preferably up to wOEW.Moreover, in close cooperation the potential of solid metallic SERS targets is to be investigated, which might simultaneously be used as electrical contacts or mirror layers for the EWOD-(w)OEW technologies. Multifunctionality of components is to be considered as inherently positive for further miniaturization of DMF lab chips.In principle, for any of the SERS target alternatives any of the mentioned actuation variants, i. e. EWOD, OEW, or wOEW, might be used. The (preliminary) allocation in the work program is owed to the temporal coordination of work packages of both groups.In case of need, for droplet actuation OEW (compared with wOEW) or even EWOD (compared with wOEW and OEW) might act as a fall-back position. Even the combination of DMF and SERS and EWOD actuation would be new.
导电液滴可以通过电介质电润湿 (EWOD) 和光电润湿 (OEW) 来驱动。原则上,OEW 控制光波甚至可以在液滴下方的层序列内进行波导(想法 Fouckhardt,基于波导的 OEW = wOEW)。一个重要的应用是化学芯片大小的实验室中数字微流控(DMF,芯片实验室2.0)中的液滴操纵。数字微流控在小型化化学领域取得突破的一个障碍是缺乏灵敏、非破坏性的检测方法,从而可以毫无疑问地识别DMF芯片上离散液滴中的化学物质。在此提出的项目中,表面增强拉曼散射或光谱学(SERS)将首次在芯片上用于此目的(贝尔德的想法),这将使可良好评估的振动光谱成为可能。通过分析物分子(液滴内)的相互作用 e. g。当金属纳米颗粒分散在液滴中时,应该可以获得高信号放大。该项目的目的是首次将DMF和SERS结合起来,并通过EWOD-OEW-wOEW同时进行液滴驱动。通过液滴运动的光学启动,应该出现实现朴素的芯片实验室系统的新机会。Belder 和 Fouckhardt 团队的合作应该提供协同效应,从而使 DMF 技术在化学实验室芯片方面的突破成为可能。 Belder 小组专注于 DMF 系统内的 SERS 检测。 Fouckhardt 小组专注于通过 EWOD 和 OEW 进一步开发液滴驱动,最好达到 wOEW。此外,通过密切合作,将研究固体金属 SERS 目标的潜力,该目标可能同时用作 EWOD-(w)OEW 技术的电接触或镜面层。组件的多功能性被认为对于 DMF 实验室芯片的进一步小型化具有内在的积极作用。原则上,对于任何 SERS 目标替代方案,任何提到的驱动变体,即。 e.可以使用 EWOD、OEW 或 wOEW。工作计划中的(初步)分配归功于两个小组工作包的时间协调。在需要的情况下,对于液滴驱动OEW(与wOEW相比)甚至EWOD(与wOEW和OEW相比)可以作为后备位置。甚至 DMF 和 SERS 以及 EWOD 驱动的组合也是新的。

项目成果

期刊论文数量(5)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Microfluidic Optical Shutter Flexibly - Actuated via Electrowetting-on-Dielectrics with
  • DOI:
    10.1155/2017/7610652
  • 发表时间:
    2017-12
  • 期刊:
  • 影响因子:
    0
  • 作者:
    H. Fouckhardt;J. Strassner;Carina Heisel;Dominic Palm;Christoph Doering
  • 通讯作者:
    H. Fouckhardt;J. Strassner;Carina Heisel;Dominic Palm;Christoph Doering
Optoelectrowetting (OEW) with push-actuation of microdroplets at small frequencies and OEW equations revisited
  • DOI:
    10.1016/j.sna.2021.113331
  • 发表时间:
    2022-02-01
  • 期刊:
  • 影响因子:
    4.6
  • 作者:
    Strassner, Johannes;Doering, Christoph;Fouckhardt, Henning
  • 通讯作者:
    Fouckhardt, Henning
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Professor Dr. Detlev Belder其他文献

Professor Dr. Detlev Belder的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Professor Dr. Detlev Belder', 18)}}的其他基金

Ion mobility spectrometry coupled to chip-based electrochromatography
离子迁移谱与基于芯片的电色谱耦合
  • 批准号:
    396430937
  • 财政年份:
    2018
  • 资助金额:
    --
  • 项目类别:
    Research Grants
Two-dimensional high performance liquid chromatography in microfluidic chip devices
微流控芯片装置中的二维高效液相色谱
  • 批准号:
    371350234
  • 财政年份:
    2017
  • 资助金额:
    --
  • 项目类别:
    Research Grants
Monitoring Chip Based Electrophoretic Separations with Surface Enhanced Raman Spectroscopy
使用表面增强拉曼光谱监测基于芯片的电泳分离
  • 批准号:
    273006689
  • 财政年份:
    2016
  • 资助金额:
    --
  • 项目类别:
    Research Grants
Advanced technologies for integrated micro systems
集成微系统的先进技术
  • 批准号:
    275695947
  • 财政年份:
    2015
  • 资助金额:
    --
  • 项目类别:
    Research Units
From discrete particle to single cell catalysis
从离散颗粒到单细胞催化
  • 批准号:
    275564491
  • 财政年份:
    2015
  • 资助金额:
    --
  • 项目类别:
    Research Units
Coordination Funds
协调基金
  • 批准号:
    275701109
  • 财政年份:
    2015
  • 资助金额:
    --
  • 项目类别:
    Research Units
Time resolved fluorescence detection utilising two photon excitation in microfluidic separation systems
在微流体分离系统中利用两个光子激发进行时间分辨荧光检测
  • 批准号:
    222164465
  • 财政年份:
    2012
  • 资助金额:
    --
  • 项目类别:
    Research Grants
Totvolumenfreie Kopplung von Mikro-Freifluss-Elektrophorese mit der Nanospray-Massenspektrometrie
微自由流电泳与纳喷雾质谱的无死体积耦合
  • 批准号:
    171009439
  • 财政年份:
    2010
  • 资助金额:
    --
  • 项目类别:
    Research Grants
Mikrofluidische Chips für die Elektrophorese in Dünnschicht-Sandwich-Bauweise
用于薄膜夹层结构中电泳的微流控芯片
  • 批准号:
    24510882
  • 财政年份:
    2006
  • 资助金额:
    --
  • 项目类别:
    Research Grants
Mikrofluidische Polymerchips mit hydrophilen Kanaloberflächen für die Mikrochip-Elektrophorese
用于微芯片电泳的具有亲水通道表面的微流控聚合物芯片
  • 批准号:
    5435757
  • 财政年份:
    2004
  • 资助金额:
    --
  • 项目类别:
    Research Grants

相似国自然基金

超声行波微流体驱动机理的试验研究
  • 批准号:
    51075243
  • 批准年份:
    2010
  • 资助金额:
    39.0 万元
  • 项目类别:
    面上项目

相似海外基金

Microfluidics to explore the uptake of nanoparticles by endothelial cells
微流体技术探索内皮细胞对纳米粒子的摄取
  • 批准号:
    DP240101579
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Discovery Projects
Advancing bioelectronics with silicon carbide on microfluidics
利用碳化硅微流体技术推进生物电子学
  • 批准号:
    DE240100408
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Discovery Early Career Researcher Award
Elastic turbulence in micro canopy flows, effects of rheology and geometry
微冠层流动中的弹性湍流、流变学和几何形状的影响
  • 批准号:
    23K19103
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
    Grant-in-Aid for Research Activity Start-up
A novel diagnostic tool leveraging AI for protein design and microfluidics for better cell therapy management
一种利用人工智能进行蛋白质设计和微流体技术以实现更好的细胞治疗管理的新型诊断工具
  • 批准号:
    10082156
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
    Collaborative R&D
Design and development of new Lipid Nano Particle delivery systems for new RNA-based c therapeutics: A rationally designed chemistry and microfluidics
设计和开发新型脂质纳米粒子递送系统,用于新型基于 RNA 的 c 疗法:合理设计的化学和微流体
  • 批准号:
    2889386
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
    Studentship
Laryngotracheal Reconstruction with Engineered Cartilage
用工程软骨重建喉气管
  • 批准号:
    10660455
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
A point-of-care salivary cytokine test for early detection of oral cancer
用于早期发现口腔癌的即时唾液细胞因子检测
  • 批准号:
    10760626
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
Probing Amyloid Fibril Self-Assembly with Network Hamiltonian Simulations in Explicit Space
用显式空间中的网络哈密顿模拟探测淀粉样蛋白原纤维的自组装
  • 批准号:
    10715891
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
Engineered TCR-Treg Cell Therapies Targeting Type 1 Diabetes Autoantigens
针对 1 型糖尿病自身抗原的工程化 TCR-Treg 细胞疗法
  • 批准号:
    10764143
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
Mass spectrometry for highly sensitive and sample-sparing analysis of extracellular vesicles in liver diseases
用于肝脏疾病细胞外囊泡高灵敏度和样品节省分析的质谱法
  • 批准号:
    10736006
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了