Comprehensive analysis of glycerol metabolism in archaea

最近，我们发现，甘油代谢途径的超嗜热古菌，Thermococcus kodakarensis KOD1，是相当简单的比较与其他生物。此外，甘油代谢的调节被发现是独立于中央代谢途径。通过对三个甘油代谢基因缺失突变体的培养试验和对各基因产物的进一步生化分析，发现甘油在T. kodakarensis KOD1.

Recently, we have found that the glycerol metabolic pathway of a hyperthermophilic archaeon, Thermococcus kodakarensis KOD1, is quite simple to compare with those of other organisms. Also the regulation of the glycerol metabolism was found to be independent from the central metabolic pathway. Through the cultivation test of deletion mutant of three genes of glycerol metabolism and the further biochemical analysis of each product of those genes, glycerol is not used as the carbon source but used for cell adaptation to oxygen stress and osmotic stress in T. kodakarensis KOD1.