Roles of Polycomb-group in links between metabolism and cancer

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Massive proliferation of cancer cells needs energy produced mainly by activating glycolysis. On the other hand, it is thought that elevated activities of Polycomb-group (PcG) proteins are one of causes for tumorigenesis. Understanding them will be helpful for cancer therapies. We have already identified mine metabolic kinases, which might affect PcG functions. This evidence has made us speculate interdependence between energy metabolism and PcG functions in cancer cells. In this study, we addressed this hypothesis by using gene knockdown experiments and co-immunoprecipitation assay, revealing that three of them could have something to do with PcG proteins or their functions. These results are supporting our hypothesis. We therefore believe that this project is worth being investigated continuously, contributing to applied medical science.