Immunomodulating effects on nano size particles which used as food additives.
Immunomodulating effects on nano size particles which used as food additives.
批准号:
25670309
负责人:
YOSHIDA Takahiko
金额:
$2.25万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2013
资助国家:
日本
项目状态:
已结题
起止时间:
2013-04-01 至 2014-03-31
中文摘要
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英文摘要
We prepared the animal pellet food contained nano size particles (20nm and 200nm) of titanium oxide and gave to experimental mice for 50 days. After the exposure period, we obtained the spleen and prepared single cell suspension and used for the basic test of immune responses. We detected the immune oppressive effect among 20nm titanium oxide particle exposed group in dose-dependently although it was not significant. At the standing point of view of food safety, we have better to evaluate the effects on local immune system/response such as gastrointestinal immunity of nano size titanium oxide particles.
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