Immunomodulating effects on nano size particles which used as food additives.

对用作食品添加剂的纳米颗粒的免疫调节作用。

• 批准号: 25670309
• 负责人: YOSHIDA Takahiko
• 金额: $ 2.25万
• 依托单位: Asahikawa Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2013
• 资助国家: 日本
• 起止时间: 2013-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-25670309/
• 关键词: ナノ粒子; 酸化チタン; 食品添加物; 免疫応答; 免疫抑制; マウス; 経消化管投与

We prepared the animal pellet food contained nano size particles (20nm and 200nm) of titanium oxide and gave to experimental mice for 50 days. After the exposure period, we obtained the spleen and prepared single cell suspension and used for the basic test of immune responses. We detected the immune oppressive effect among 20nm titanium oxide particle exposed group in dose-dependently although it was not significant. At the standing point of view of food safety, we have better to evaluate the effects on local immune system/response such as gastrointestinal immunity of nano size titanium oxide particles.

我们制备了含有纳米级氧化钛颗粒（20 nm和200 nm）的动物颗粒食品，并给实验小鼠50天。 暴露期结束后，取脾脏，制备单细胞悬液，用于免疫应答的基础试验。 20 nm氧化钛颗粒暴露组的免疫抑制作用虽不显著，但呈剂量依赖性。 从食品安全的角度来看，我们更好地评估纳米氧化钛颗粒对局部免疫系统/反应如胃肠道免疫的影响。