Investigation of the significance of MRTF-A, a co-activator of SRF, in the development of obesity that is an underlying risk factor for cardiovascular diseases

研究 MRTF-A（SRF 的共激活剂）在肥胖发展中的重要性，肥胖是心血管疾病的潜在危险因素

• 批准号: 16K15442
• 负责人: KUWAHARA KOICHIRO
• 金额: $ 2.25万
• 依托单位: Shinshu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2016
• 资助国家: 日本
• 起止时间: 2016-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16K15442/
• 关键词: 分子心臓学; 転写因子; シグナル伝達; 糖代謝; 肥満; 脂肪分化; 分子心臓病学; 転写調節; メタボリックシンドローム

项目成果

Transcriptional pathways underling the development of heart failure

心力衰竭发展的转录途径

• 发表时间: 2018
• 作者: Ohno S;Yokoi H;Mori K;Kasahara M;Kuwahara K;Fujikura J;Naito M;Kuwabara T;Imamaki H;Ishii A;Saleem MA;Numata T;Mori Y;Nakao K;Yanagita M;Mukoyama M;桑原宏一郎
• 通讯作者: 桑原宏一郎

Endothelial dysfunction underlies blood pressure elevation in endothelium-specific C-type natriuretic peptide knockout mice.

内皮特异性 C 型利尿钠肽敲除小鼠血压升高的原因是内皮功能障碍。

• 发表时间: 2017
• 作者: Kuwahara K;Nakao K;Nishikimi T;nakagawa Y;Tokudome T;Minamino N;Kimura T;Kangawa K;Nakao K
• 通讯作者: Nakao K

MiR30-GALNT1/2 axis-mediated glycosylation at threonine 48 and 71 plays an essential role in the increased secretion of unprocessed pro-brain natriuretic peptide by failing hearts

MiR30-GALNT1/2 轴介导的苏氨酸 48 和 71 糖基化在衰竭心脏增加未加工的前脑钠尿肽分泌中发挥重要作用

• 发表时间: 2016
• 作者: Kuwahara K;Nakagawa Y;Nishikimi T;Kangawa K;Minamino N;Nakao K;Kimura T.
• 通讯作者: Kimura T.

2-year natural history of lower limbs in patients with end-stage renal disease on hemodialysis due to diabetic nephropathy; from PREDICT study.

因糖尿病肾病而进行血液透析的终末期肾病患者下肢2年自然史；

• 发表时间: 2017
• 作者: Kato T;Miyashita Y;Miura T;Kanno Y;Sone H;Tokoo M;Ako S;Mizukami E;Terashima M;Yokota D;Nakagawa M;Fujimori Y;Higuchi M;Mochidome T;Sakai T;Senda K;Oguchi Y;Yamasaki S;Saigusa T;Ebisawa S;Okada A;Motoki H;Kuwahara K
• 通讯作者: Kuwahara K

Development and Validation of a Novel Scoring System for Predicting Chronic Outcome After Percutaneous Coronary Intervention for Coronary Chronic Total Occlusion

开发和验证一种新型评分系统，用于预测冠状动脉慢性完全闭塞经皮冠状动脉介入治疗后的慢性结果

• 发表时间: 2017
• 作者: Ebisawa S;Kosaka S;Yamane M;Muramatsu T;Okamura A;Kashima Y;Matsuno S;Sakurada M;Kijima M;Tanabe M;Habara M;Kuwahara K.
• 通讯作者: Kuwahara K.