Mechanism of pulmonary fibrosis induced by deranged fatty acid composition

脂肪酸组成紊乱诱发肺纤维化的机制

• 批准号: 16K15456
• 负责人: Kurabayashi Masahiko
• 金额: $ 2.16万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2016
• 资助国家: 日本
• 起止时间: 2016-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16K15456/
• 关键词: 脂肪酸; サーファクタント; 線維化; 肺気腫; 飽和脂肪酸; 血管平滑筋; 肺線維症; 肺胞上皮細胞; 肺線維化; 肺胞上皮

项目成果

A shift of energy substrate shift from fatty acids to glucose exacerbates cardiac dysfunction during pressure overload: A lesson learned from fatty acid binding protein-4 and -5 knockout mice

能量底物从脂肪酸向葡萄糖的转变会加剧压力超负荷期间的心脏功能障碍：从脂肪酸结合蛋白-4和-5敲除小鼠中吸取的教训

• 发表时间: 2017
• 作者: Tsukuda Y;Suda G;Tsunematsu S;Ito J;Sato F;Terashita K;Nakai M;Sho T;Maehara O;Shimazaki T;Kimura M;Morikawa K;Natsuizaka M;Ogawa K;Ohnishi S;Chuma M;Sakamoto N;Yogi Umbarawan
• 通讯作者: Yogi Umbarawan

Elovl6-driven fatty acid metabolism regulates hypertrophic response in the heart subjected to pressure overload in mice.

Elovl6 驱动的脂肪酸代谢调节小鼠压力超负荷时心脏的肥大反应。

• 发表时间: 2018
• 作者: Hiroaki Sunaga;Hiroki Matsui;Tatsuya Iso;Yogi Umbarawan;Takashi Matsuzaka;Hitoshi Shimano;Norimichi Koitabashi;Tomoyuki Yokoyama;Masahiko Kurabayashi.
• 通讯作者: Masahiko Kurabayashi.

Fibroblast growth factor 23 inhibits osteoblastic gene expression and induces osteoprotegerin in vascular smooth muscle cells

• DOI: 10.1016/j.atherosclerosis.2016.08.010
• 发表时间: 2016-10-01
• 期刊: ATHEROSCLEROSIS
• 影响因子: 5.3
• 作者: Nakahara, Takehiro;Kawai-Kowase, Keiko;Kurabayashi, Masahiko
• 通讯作者: Kurabayashi, Masahiko