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Extinction of constitutive heterochromatin blocks in humans: structural analysis for clarification of mechanisms

Extinction of constitutive heterochromatin blocks in humans: structural analysis for clarification of mechanisms
人类组成型异染色质块的消失:结构分析以阐明机制
批准号:
23657165
负责人:
KOGA Akihiko
金额:
$2.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

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中文摘要
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英文摘要
This study deals with rapid changes in the amount of constitutive heterochromatin, including emergence, amplification, reduction and extinction. These changes are frequently observed in many primate groups, such as hominids and gibbons. Cloning, sequencing and hybridization experiments revealed that such rapid changes are associated with integration of repetitive sequencesinto the centromere or telomere and the speed of change depends on their nucleotide sequences.
期刊论文(15)
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会议论文
DOI: --
发表时间: 2013
期刊: DNA Research
影响因子: 4.1
作者: [Prakhongcheep O, Chaiprasertsri N, Terada S, Hirai Y, Srikulnath K, Hirai H, *Koga A]
通讯作者: *Koga A
テナガザルの染色体端部にある大規模ヘテロクロマチンの主成分
长臂猿染色体末端大规模异染色质的主要成分
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [I H Susilowati, A Yasukouchi, 平井啓久・原暢・平井百合子・古賀章彦]
通讯作者: 平井啓久・原暢・平井百合子・古賀章彦
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [S.Kawaguchi, O.Kambara, M.Shibata, H.Kandori, K.Tominaga, 古賀章彦(京都大・霊長研),原暢(京都大・霊長研),Israt Jahan(京都大・霊長研),平井百合子(京都大・霊長研),平井啓久(京都大・霊長研)]
通讯作者: 古賀章彦(京都大・霊長研),原暢(京都大・霊長研),Israt Jahan(京都大・霊長研),平井百合子(京都大・霊長研),平井啓久(京都大・霊長研)
京都大学霊長類研究所
京都大学灵长类研究所
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
9
    Rapid karyotypic changes in a primate taxon: possibility of participation of repetitive DNA as chromosome breakage inducer
    • 批准号:
      25650152
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.58万
    • 财政年份:
      2013
    • 负责人:
      KOGA Akihiko
    • 依托单位:
    Fluctuation in the size of species-specific repetitive DNA of hominoids: quantitative analysis by comparative genomics
    • 批准号:
      24370098
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $10.98万
    • 财政年份:
      2012
    • 负责人:
      KOGA Akihiko
    • 依托单位:
    Factors causing sudden increase in the transposition frequency of transposable elements in medaka fish
    Transposition mechanisms and biotechnology application of the medaka fish To12 transposable element
    海外基金