Rational design of mixing ratio of food-derived anti-inflammatory factors based on molecular mechanisms.
Rational design of mixing ratio of food-derived anti-inflammatory factors based on molecular mechanisms.
批准号:
23658119
负责人:
OHIGASHI Hajime
金额:
$1.5万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
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英文摘要
From isobolograms of various food-derived NO production-suppressive compounds, Curcumin (CUR) and Resveratrol (RES) showed synergistic effects. While CUR and Luteolin (LUT) also showed synergistic effect, Chrysin (CHR) and Apigenin (API), other flavones with NO production-suppressive activity, did not show synergism with CUR. From Western blot analysis, combination of not only CUR and LUT but also CUR and RES showed enhancement effects in inhibitory rate of LPS-induced iNOS protein production. Because LUT has characteristic catechol moiety in the B-ring, which is not resided in CHR and API, the moiety may be associated in the synergism between LUT and CUR.
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DOI:
10.1016/j.phytochem.2012.04.010
发表时间:
2012
期刊:
Phytochemistry
影响因子:
3.8
作者:
[Mukai, R., Kawabata, K., Otsuka, S., Ishisaka, A., Kawai, Y., Ji, Z.S., Tsuboi, H., and Terao, J., N. Hirai]
通讯作者:
N. Hirai
ケルセチンによるビフィズス菌の抗炎症活性増強効果
槲皮素增强双歧杆菌抗炎活性的作用
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[坂野太研, 川畑球一,大東 肇]
通讯作者:
川畑球一,大東 肇
「ヒトが食べるくすり、チンパンジーがたべるくすり」
“人类吃的毒品和黑猩猩吃的毒品”
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[川畑球一, 奥村真由, 宮下美希, 杉山友太, 高橋正和, 大東 肇, 高橋正和, 大東 肇]
通讯作者:
大東 肇
キチン分解細菌由来金属プロテアーゼNPR-7のプロ配列に関する構造機能解析
几丁质降解细菌金属蛋白酶 NPR-7 前序列的结构和功能分析
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[川畑球一, 奥村真由, 宮下美希, 杉山友太, 高橋正和, 大東 肇, 高橋正和, 大東 肇, 大倉克摩, 三浦優子, 大倉克摩, 上前知之, 川畑球一, Takahashi M., Takahashi M., Ohkura K., 三浦優子]
通讯作者:
三浦優子
Purification, identification, and seasonal quantification analyses of nitric oxide generation inhibitory compounds in Spinacia oleracea
菠菜中一氧化氮生成抑制化合物的纯化、鉴定和季节定量分析
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Takahashi M., Nakamura S., Sugiyama Y., Kubo Y., Kobayashi K., Murakami A., Irie K., Kawabata K., and Ohigashi H]
通讯作者:
and Ohigashi H
共 40 条
Exploration of anti-inflammatory food factors from plant diets, and chemical classification of such factors based on their action mechanisms
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批准号:20580139
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.0万
-
财政年份:2008
-
负责人:OHIGASHI Hajime
-
依托单位:
Development of new agents that regulate cellular signal transduction
-
批准号:15208012
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$28.45万
-
财政年份:2003
-
负责人:OHIGASHI Hajime
-
依托单位:
Prevention of colon cancer with the de novo suppressants of iNOS and COX-2 expressions
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批准号:12556018
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$7.68万
-
财政年份:2000
-
负责人:OHIGASHI Hajime
-
依托单位:
Ecochemical study on the medicinal plant use of primates in the wild
-
批准号:08306005
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$9.79万
-
财政年份:1996
-
负责人:OHIGASHI Hajime
-
依托单位:
Bioactive phytochemicals from African savanna woodland
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批准号:07041139
-
项目类别:Grant-in-Aid for international Scientific Research
-
资助金额:$2.62万
-
财政年份:1995
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负责人:OHIGASHI Hajime
-
依托单位:
Plants medicinally used by chimpnazees in the wild, and their biologically active constituents
-
批准号:06303012
-
项目类别:Grant-in-Aid for Co-operative Research (A)
-
资助金额:$8.38万
-
财政年份:1994
-
负责人:OHIGASHI Hajime
-
依托单位:
Evaluation of dietary plants for superoxide generation (or its inhibition), or scavening activities, and their active constituents
-
批准号:06660156
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.28万
-
财政年份:1994
-
负责人:OHIGASHI Hajime
-
依托单位:
Antiparasitic Agents from Wild Primate Medicinal Plants
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批准号:06044122
-
项目类别:Grant-in-Aid for international Scientific Research
-
资助金额:$2.05万
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财政年份:1994
-
负责人:OHIGASHI Hajime
-
依托单位:
Plants non-nutritiously ingested by wild chimpanzee, and their bioactive constituents
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批准号:04660143
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项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.28万
-
财政年份:1992
-
负责人:OHIGASHI Hajime
-
依托单位:
海外基金