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New Method for Local Drug Delivery using Resorbable Base Material in Periodontal Therapy

牙周治疗中使用可吸收基材局部给药的新方法

基本信息

批准号：
60870069
负责人：
NOGUCHI Toshihide
金额：
$ 1.98万
依托单位：
Tokyo Medical and Dental University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research
财政年份：
1985
资助国家：
日本
起止时间：
1985 至 1986
项目状态：
已结题

项目摘要

For the purpose of controlling the subgingival plaque in different ways from the conventional methods, several studies have been made. These methods, using hollow fiber devices and acrylic resin strips seem to be effective in changing the microflora in the periodontal pockets. However, for the routine use of these methods in the treatment of the periodontal disease, they have some problems. One of problems of these methods is to require the removal of the carrier from the pockets after the release of the drugs. The other is the lack of retension of the carrier in periodontal pockets. To overcome these problems, we found a new method for the access to the subgingival plaque. The base material used is made of hydroxypropylcellurose (HPC). HPC dissolves slowly in contact with the saliva or gingival crevicular fluid and adheres to both the tooth surface and the soft tissue. Using this material containing tetracycrine(TC) or chlorhexidine(CH) prepared in the form of strips, it has been found to be possible to deliver the drugs of directly to the periodontal pockets. Effects of this method on the microbial composition in periodontal pockets and clinical symptoms were studied. Changes of clinical parameter, reduction of probing depth and bleeding on probing were observed only in the pockets in which TC administrated. Changes of microbial composition of subgingival plaque were found both in TC and CH administrated pockets.To compare systemic administration with local drug administration, antibiotics (tetracycline, minocycline) applied systematically or locally to patients with acute periodontitis. Seven days after administration of antibiotics, degree of pain, bleeding on probing and probing depth were evaluated. As the result, no significant different were seen between local and systemic administration.

为了以不同于传统方法的方式控制龈下菌斑，已经进行了一些研究。这些方法，使用中空纤维装置和丙烯酸树脂条似乎是有效的改变牙周袋中的微生物群落。然而，这些方法在牙周病的治疗中的常规使用，它们存在一些问题。这些方法的问题之一是需要在药物释放后从袋中取出载体。另一种是载体在牙周袋中缺乏固位力。为了克服这些问题，我们找到了一种新的方法来进入龈下菌斑。使用的基础材料由羟丙基纤维素（HPC）制成。HPC在与唾液或龈沟液接触时缓慢溶解，并粘附在牙齿表面和软组织上。已经发现，使用以条的形式制备的含有四环素（TC）或氯己定（CH）的这种材料，可以将药物直接递送到牙周袋。观察该方法对牙周袋内微生物组成及临床症状的影响。仅在TC给药的囊袋中观察到临床参数的变化、探诊深度的减少和探诊出血。为比较全身用药与局部用药对急性牙周炎患者的影响，对四环素、米诺环素等抗生素进行了全身用药与局部用药的比较。抗生素给药后7天，评价疼痛程度、探诊出血和探诊深度。结果，局部和全身给药之间未见显著差异。