Metagenomic Analysis of Oral Microbiota from Normal Subjects and Patients with Periodontal Disease

对牙周健康受试者和牙周炎患者的牙菌斑微生物群进行宏基因组学分析。对七个DNA样本的深度测序共检测到996种，并显示牙菌斑中的微生物多样性比以前已知的要大得多。将这些样品的功能分组概况与其他环境宏基因组数据集（例如人类肠道微生物群）进行比较。在菌斑样本中观察到“防御机制”和“碳水化合物运输和代谢”类别的基因富集。

A metagenomic analysis of dental plaque microbiota obtained from periodontal healthy subjects and periodontitis patients was performed. The deep sequencing of the seven DNA samples detected total of 996 species and revealed substantially greater microbial diversity in the dental plaque than previously known. The functional binning profiles of these samples were compared with other environmental metagenome datasets such as human gut microbiota. Enrichments of genes in the categories of 'Defense mechanism' and 'carbon hydrate transport and metabolism' were observed in plaque samples.