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Basic Research for Aetiology and Pathology of Periodontal Disease

牙周病病因病理基础研究

基本信息

批准号：
61480396
负责人：
NOGUCHI Toshihide
金额：
$ 2.75万
依托单位：
Department of Periodontology,School of Dentistry,Aaichigakuin Universi (1987-1988)Tokyo Medical and Dental University (1986)
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1986
资助国家：
日本
起止时间：
1986 至 1988
项目状态：
已结题

项目摘要

Based on the microbiological studies, it is well documented that the subgingival plaque, in which the gram-negative anaerobic rods are predominant, is associated with the destructive periodontal disease. In this investigation, we used hydroxypropylcellulose (HPC) as the base material and tried to apply the drugs directly to the subgingival plaque, the HPC containing 1% tetracycline (TC) formend solid and elastic strips. The in vitro release of the drugs from these strips showed almost 100% of this material added was released. From the clinical results obtained in this study, it was found that gingival index, probing depth and bleeding on probing tended to be less when the placebo strips were inserted. The results obtained from the microbiological studies showed that the TC containing HPC altered effectively the microbiological composition of the subginigival plaque.This new direct drug delivery system with HPC used as a base material was found to be effctive in changiang the composition of bacteria in the subgingival plaque and inproducing signs of clinical improvement.A note of caution should be added concerning the possible adverse in the subgingival flora which can be brought about by locally delivered tetracycline. Mandel et al. (1986) have shown that locally applied tetracycline in periodontal pockets infected with actinobacillus actinomycetemcomitans can actually result in a shift in the flora of such pockets to almost pure cultures of A. actinomycetemcomitans, associated with a period of active periodontal tissue destruction. It is likely that this results from re-seeding of the tetracycline-suppressed pocket by A.actinomycetemcomitans, which has invaded the gingival connective tissue and which remains viable in these tissue.

微生物学研究表明，以革兰氏阴性厌氧菌为主的龈下菌斑与破坏性牙周病有关。本研究以羟丙基纤维素(HPC)为基材，尝试将药物直接涂抹在含1%四环素(TC)的HPC上，形成固体条和弹性条。这些药条的体外释放显示添加的材料几乎100%被释放。从本研究的临床结果中发现，当安慰剂条插入时，牙龈指数、探诊深度和探诊时的出血倾向于较少。微生物学研究结果表明，含有HPC的TC有效地改变了龈下菌斑的微生物组成。以HPC为基质的这种新的直接给药系统在常江被发现有效地改变了龈下菌斑中的细菌组成和临床改善的迹象。四环素局部给药可能会对龈下菌群产生不良影响，值得注意。Mandel等人。(1986)的研究表明，在感染了伴生放线杆菌的牙周袋中局部应用四环素实际上会导致这种袋中的菌群转变为几乎纯的伴生放线杆菌培养，并伴随一段时间的牙周组织活跃破坏。这很可能是因为伴生放线菌对四环素抑制的袋子进行了重新播种，这种细菌已经侵入了牙龈结缔组织，并在这些组织中仍然存活。