Mathematical Model of Arrhythmia Generating mechanism Besed on the Modulated Parasystole Theory

为了阐明心律失常的机制，建立了心脏传导系统的数学模型。该模型由模拟心肌细胞传导特性的元件网络组成，其中每个元件由来自动作电位的一组唯一的时间参数定义。将数学描述从网络结构中分离出来，并定义了非线性同步理论，从而可以对不同网络规模的模型进行建模，并应用有限元法进行精确建模。此外，我们有可能共同构建关于心肌细胞代谢和离子通道功能之间关系的先验知识。该模型的细节包括三个部分，即，脉冲传播、异位兴奋产生机制和电位产生。在逆解方法中，由体表电位分布数据计算了心内膜细胞结构内兴奋波前的到达时间分布。参考传导过程模型，从上述相同的数据估计参数。总之，可以相信，不同机制导致的心律失常的建模是一个重要的领域，该模型已被证明是有用的，不仅为心脏电生理的基本理解，而且为自动心律失常识别和除颤治疗的前沿技术的保存，例如，改进房室感知监测。

A mathematical model of the cardiac conduction system has been developed in order to clarify the mechanisms of cardiac arrhythmia. The model is consist of the network of elements which simulate the conductivity chatacteristics of the heart muscle scintidium, where each element is defines by a unique set of time parameters from the action potential. The mathematical desctiption is separated from the network structure, and defined ad a non-linear synchronization theory, thus making is possible to rum the model with different network sizes, and to apply the finite element method for precise modeling. In addition, id became possible to construct together an a prio'ri knowledge about the relationship between cardiac cell metabolism and ion channel function. The details of the model consist of three parts, i.e., impulse progaration, ectopic excitation generation mechanism and electopotential generation. In the inverse solution approach, the arrival time disteibution of excitation front within cardiac scintidium cell structure were calculated from the data of body surface potential distributions. Referring to the conduction process model, the parameters is estimated from the above same data. Conclusively, it is believable that modeling of the different mechanisms which cause cardiac arrhythmias is an important area and that the model has been shown to be useful not only for basic understaunding of cardiac electric physiology, but also for the savelopment of frontier technology of an automated atthythmia recognition and a simultaneous defibrillation treatment, for an example, the improvement of atrioventriculat sensing monitor.