「DEVELOPMENT OF A STEREOTAXIC DEVICE USING SOFT X-RAY FLUOROGRAPY」

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For accurate brain stereotaxy in various experimental animal species, a device with soft X- rays was improved in this project. The fluorography of the animal head can be observed on a monitor during the brain operation, so that the efficacy and accuracy of the brain stereataxy can be greatly improved.The device is 1700 high, 2000 wide and 1150 in depth (mm). It is composed of the X-ray generator, movements for adjustment of animal position, X-ray camera, steel shield for protection of the operator from x-ray irradiation, image processor for enhancement of fluorography, a personal computer for generation of three dimensional standard axes, color monitor, micromanipulators for intracranial operation and their hydraulic driving systems.The animal is placed an a operation stage on the Movements I and II which are controlled by remote drive systems. By movement I, which can adjust the position in three dimensions (X,Y and Z) and pitching (alpha) and rolling (beta) manners, the animal head can be placed in the most appropriate position between the X-ray source and the camera. Then the animal and electrode can be moved altogether by the Movement II. By rotating the Movement II in 90 degrees, lateral and frontal views of the animal head can be observed. The videosignals are processed by a video processor and the clarity of the fluorography can be enhanced. Vertical and horizontal standard axes are generated by a personal computer, superimposed onto the fluorography of the animal head and observed on a color monitor altogether. By defining the stereotaxic zero at an appropriate structure in the skull, any position in the brain can be accessed itereotaxically.