Development of CO_2 removal membrane artificial lung for ECCO_2R

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Extracoporeal CO_2 removal (ECCO_2R) by a membrane lung appears to be a premising technique of respiratory support in the treatment of acute respiratory failure. CO_2 transfer performance in a membrane lung depends on both membrane and blood phase resistance. In the present study we have found out the way of improving CO_2 removal rate by means of microporous tubes materials offering negligible membrane resistance and various configuration of curved tubes reducing the blood phase resistance. CO_2 removal rate for various type of curved tubes was evaluated by ex vivo canine experiments and CO_2 removal efficiency went up to more than five times as large as that for straight tube. However, the membrane permeability of CO_2 was deteriorated by plasma leakage through pores. In order to evaluate the deterioration, the wettability of microporous membrane was measured by the capillarography method.As a result of evaluating CO_2 removal rate we found the design features of the highly efficient CO_2 removal lung which could be successfully applied to ECCO_2R.