Psychophysiological methods in the context of pharmacological and behavioral treatment approaches of Gilles-de-la-Tourette Syndrome

点击翻译按钮获取中文摘要

Goal of the intended project is to analyze the mode of action of pharmacological and behavioral therapeutic interventions in the treatment of Gilles-de-la-Tourette Syndrome (GTS) using psychophysiological methods. The primary evaluation relates to the analysis of action control processes using EEG techniques on the basis of computational basal ganglia models and the neurobiology of fronto-striatal circuits. As secondary parameters, inventories assessing the severeness of GTS and quality of life will be used and this data integrated with the psychophysiological data. Besides an applied focus of research pursued in this project, the project will also provide insights into cognitive functions in one of the most prevalent neuropsychiatric disorders in childhood and youth, which may be viewed as a disease-model of dopaminergic hyperfunction. Results of the study will therefore contribute to the understanding of the processes underlying treatment of GTS and to role of fronto-striatal circuits for cognitive control processes.