Neuropsychopharmacology of event file coding in GTS using EEG-beamforming

本研究单位的中心假设是，Gilles de la Tourette综合征（GTS）可能不被视为一种“经典的”运动障碍，而应该被概念化为一种影响感知和行动如何整合的障碍。因此，了解用于治疗GTS的神经药理干预如何影响与感知和行动整合相关的神经机制是至关重要的。该项目研究了GTS中的药物干预如何调节动作、对象和事件文件编码。这些药理作用背后的电生理机制将通过脑电图、事件相关电位、时频分解和波束形成方法，以及从神经网络角度评估信息处理效率的方法来研究。我们预计主要是事件和动作文件编码，而不是那么多的目标文件编码受到药理学治疗的影响。此外，我们假设抽搐是在自由计时（非药物治疗）状态下集成在事件编码过程中的，而不是在药物治疗状态下。

The central assumption of this Research Unit is that Gilles de la Tourette syndrome (GTS) might not be viewed as a ‘classical‘ movement disorder but should rather be conceptualised as a disorder affecting how perception and action are integrated. It is therefore central to understand how neuropharmacological interventions used to treat GTS affect the neural mechanisms associated with the integration of perception and action. This project examines how action, object and event file coding are modulated by a pharmacological intervention in GTS. The electrophysiological mechanisms underlying these pharmacological effects will be examined using EEG, employing event-related potentials, time-frequency decomposition and beamforming methods, as well as methods evaluating the efficiency of information processing from a neural network perspective. We expect that predominantly event and action file coding, but not so much object file coding are affected by pharmacological treatment. Moreover, we assume that tics are integrated in event coding processes in a freely ticcing (un-medicated) state, but not in the medicated state.