Neuropsychopharmacology of event file coding in GTS using EEG-beamforming

使用 EEG 波束形成的 GTS 事件文件编码的神经精神药理学

• 批准号: 396577418
• 负责人: Professor Dr. Christian Beste
• 金额: --
• 依托单位: Klinik und Poliklinik für Kinder- und Jugendpsychiatrie und -psychotherapie
• 依托单位国家: 德国
• 项目类别: Research Units
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/396577418?language=en
• 关键词: Neuropsychopharmacology; event; file; coding; GTS

The central assumption of this Research Unit is that Gilles de la Tourette syndrome (GTS) might not be viewed as a ‘classical‘ movement disorder but should rather be conceptualised as a disorder affecting how perception and action are integrated. It is therefore central to understand how neuropharmacological interventions used to treat GTS affect the neural mechanisms associated with the integration of perception and action. This project examines how action, object and event file coding are modulated by a pharmacological intervention in GTS. The electrophysiological mechanisms underlying these pharmacological effects will be examined using EEG, employing event-related potentials, time-frequency decomposition and beamforming methods, as well as methods evaluating the efficiency of information processing from a neural network perspective. We expect that predominantly event and action file coding, but not so much object file coding are affected by pharmacological treatment. Moreover, we assume that tics are integrated in event coding processes in a freely ticcing (un-medicated) state, but not in the medicated state.

该研究单位的核心假设是，抽动秽语综合征（GTS）可能不被视为一种“经典”运动障碍，而应该被概念化为一种影响感知和行动如何整合的疾病。因此，了解用于治疗GTS的神经药理学干预如何影响与感知和动作整合相关的神经机制是至关重要的。本项目探讨如何行动，对象和事件文件编码调制的药理干预GTS。这些药理作用的电生理机制将使用EEG，采用事件相关电位，时间-频率分解和波束形成方法，以及从神经网络的角度评估信息处理效率的方法进行检查。我们预计，主要事件和动作文件编码，但没有这么多的目标文件编码受到药物治疗的影响。此外，我们假设，抽搐是集成在事件编码过程中的一个自由ticcing（非药物）的状态，但不是在药物状态。