Dynamic surface coatings through the hierarchical self-assembly of responsive colloidal building blocks

通过响应性胶体构建块的分层自组装实现动态表面涂层

• 批准号: 426950009
• 负责人: Professor Dr. Andreas Fery
• 金额: --
• 依托单位: Leibniz-Institut für Polymerforschung Dresden (IPF)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/426950009?language=en
• 关键词: Dynamic; surface; coatings; through; hierarchical

The project aims at exploring a novel strategy for the assembly of polymeric coatings which show pronounced responsiveness towards changes in pH or irradiation with light while simultaneously providing a compartmentalized structure with nm feature sizes and full reversibility of structural changes. The assembly strategy uses different colloidal building blocks: either pH-responsive micelles formed from ampholytic triblock terpolymers are used or, as an alternative, spherical polyelectrolyte brushes with an ampholytic diblock copolymer corona are prepared. These building blocks allow multilayer formation via layer-by-layer electrostatic self-assembly. In both cases, the interactions between adjacent colloidal building blocks as well as with potential adsorbents on the surface can be controlled via external stimuli, i.e. switching from attractive to repulsive interactions can be realized. In that way, we aim at light- and pH-responsive materials which are capable of interacting with different systems upon adhesion or film formation. Whereas the incorporation of pH-sensitive segments in block copolymer-based multi-compartment micelles (MCMs) leads to charge-invertible nanostructures, light as external trigger is implemented by exploiting the photo-acidity of TiO2 upon irradiation. TiO2 can act as a light sensitizer, as illumination of TiO2 with light of suitable wavelength results in local pH changes, triggering changes in the charge and conformation of attached polyelectrolytes. The immobilization of colloidal building blocks on surfaces can be directly achieved from aqueous solutions using non-covalent interactions. Thus, coatings can be formed under environmentally friendly conditions on a large variety of surfaces including metals, metal-oxides or polymeric materials and with varying thickness. While our study is of fundamental nature, we envision potential applications of these coatings as switchable cell culture surfaces or switchable elements in 3D cell cultures in the future.

该项目旨在探索一种新型的聚合物涂层组装策略，该策略表现出对pH值变化或光线变化的反应性，同时提供了具有NM特征大小和结构变化的完全可逆性的隔室化结构。组装策略使用不同的胶体构建块：使用由两性溶解三嵌段的培训剂形成的pH响应性胶束，或者作为替代性的球形聚电解质刷，准备带有两性二孔的共聚物corona。这些构建块允许多层通过一层静电自组装形成多层。在这两种情况下，都可以通过外部刺激来控制相邻的胶体构建块以及表面上潜在吸附剂之间的相互作用，即可以实现从吸引力的互动转向排斥的相互作用。这样，我们旨在实现能够在粘附或膜形成后与不同系统相互作用的光和pH响应材料。尽管将pH敏感的片段掺入基于块共聚物的多组分胶束（MCMS）导致电荷可转化纳米结构，但通过在辐照时利用Tio2的光效率来实现光线作为外部触发。 TIO2可以充当光敏剂，作为带有合适波长的TiO2照明会导致局部pH变化，从而触发附着的聚电解质的电荷和构象的变化。可以使用非共价相互作用直接从水溶液中直接实现胶体构建块在表面上的固定化。因此，可以在环境友好的条件下在各种表面上形成涂料，包括金属，金属氧化物或聚合物材料以及厚度不同。尽管我们的研究具有基本的性质，但我们将这些涂层的潜在应用视为可切换的细胞培养表面或将来3D细胞培养物中的可切换元素。