Studies on relative hypoxia in the liver cell caused by environmental chemical agents
环境化学制剂引起肝细胞相对缺氧的研究
基本信息
- 批准号:03454205
- 负责人:
- 金额:$ 4.03万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for General Scientific Research (B)
- 财政年份:1991
- 资助国家:日本
- 起止时间:1991 至 1992
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
1. When assessing the effect of chemical agents on our health in actual environment, interactions of their effects must be considered. In this study, we have assessed effects of relative hypoxia on liver cells caused by chemical agents consumed everyday in our life by using perfused rat liver technique. Furthermore the effect of different nutritional conditions on interactions of chemical agents were also studied. 2. Effect of flufenamic acid (FA) on ethanol metabolism was studied; (1) After ethanol ingestion, blood ethanol and acetaldehyde concentrations were significantly higher in rats pretreated with FA as compared to control rats, (2) the altered metabolism was not due to the uncoupling effect of FA on mitochondria in the liver (3) but rather to a suppressive effect of FA on acetaldehyde dehydrogenase in the liver. 3. Nitrite interacted with catalase compound I followed by the decomposition of compound I to free form and the its oxidation to nitrate in the perfused rat liver, suggesting that the maximal inhibitory action was produced by 10mM blood ethanol concentration. 4. Effect of ethanol on styrene metabolism was studied. Ethanol decreased the rate of styrene metabolism under the fed condition, while ethanol increased the rate of styrene metabolism under the fasted condition. 5. Time-dependent effect of acute ethanol administration on rat locomotor acturity rhythm was observed. It was suggested that this time-dependency was mediated by physiological circadian rhythm change in oxygen demand (relative hypoxia) in the liver cell. 6. In conclusion, all these results suggested that the relative hypoxia in the liver cell produced substantial effects on living organism through ingestion or exposure of actual concentrations of chemical agents consumed in our everyday life.
1. 在实际环境中评估化学制剂对人体健康的影响时,必须考虑其相互作用。在这项研究中,我们利用灌注大鼠肝脏技术评估了我们日常生活中消耗的化学物质对肝细胞的相对缺氧影响。此外,还研究了不同营养条件对化学制剂相互作用的影响。2. 研究氟芬那酸(FA)对乙醇代谢的影响;(1)摄入乙醇后,经FA预处理的大鼠血液中乙醇和乙醛浓度明显高于对照大鼠;(2)代谢的改变不是由于FA对肝脏线粒体的解偶联作用;(3)而是由于FA对肝脏中乙醛脱氢酶的抑制作用。3. 亚硝酸盐与过氧化氢酶化合物I相互作用,化合物I在灌注的大鼠肝脏中分解为游离态并氧化为硝酸盐,表明在10mM血乙醇浓度时产生最大的抑制作用。4. 研究了乙醇对苯乙烯代谢的影响。在进料条件下,乙醇降低了苯乙烯的代谢速率,而在禁食条件下,乙醇提高了苯乙烯的代谢速率。5. 观察了急性乙醇给药对大鼠运动活动节律的时间依赖性影响。这表明这种时间依赖性是由肝细胞中需氧量(相对缺氧)的生理昼夜节律变化介导的。6. 总之,所有这些结果表明,肝细胞中的相对缺氧通过摄入或暴露于我们日常生活中消耗的实际浓度的化学制剂对生物体产生实质性影响。
项目成果
期刊论文数量(55)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
仲田 和代: "肝カタラーゼNO_2^-酸化反応に対するエタノールの影響" 日本公衆衛生雑誌. 39(10). 1078 (1992)
Kazuyo Nakada:“乙醇对肝脏过氧化氢酶 NO_2^-氧化反应的影响”日本公共卫生杂志 39(10) (1992)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
J.H.Liu, C.Sato, T.Takano and F.Marumo: "Characterization of vasopressin-mediated GSH efflux from HEP G2 cells: Significance of protein kinase C." Life Science.
J.H.Liu、C.Sato、T.Takano 和 F.Marumo:“HEP G2 细胞中加压素介导的 GSH 流出的表征:蛋白激酶 C 的意义。”
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Y.Motohashi: "Combined effects of ethanol and thoephyline on circadian rhythm in locomotor activity in the rat." Toxicology Letters. 187- (1992)
Y.Motohashi:“乙醇和茶碱对大鼠运动活动昼夜节律的综合影响。”
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
C.Sato: "V1-receptor mediated GSH efflux by vasopressin from rat hepatocyles." Life Science. 51. 507-512 (1992)
C.Sato:“V1 受体通过加压素从大鼠肝细胞介导 GSH 流出。”
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
劉 錦江: "グルタチオン代謝に及ぼすカドミウムの影響" 日本衛生学雑誌. 48(1). 148- (1993)
刘锦江:“镉对谷胱甘肽代谢的影响”日本卫生杂志48(1)(1993)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
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TAKANO Takehito其他文献
TAKANO Takehito的其他文献
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{{ truncateString('TAKANO Takehito', 18)}}的其他基金
Effects of change in natural environments in accordance with urbanization on population health
城市化带来的自然环境变化对人口健康的影响
- 批准号:
14370134 - 财政年份:2002
- 资助金额:
$ 4.03万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Health issues of risk populations associated with decay of megacities.
与特大城市衰退相关的风险人群的健康问题。
- 批准号:
12470093 - 财政年份:2000
- 资助金额:
$ 4.03万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
RESEARCH ON MONITORING OF THE CHANGE OF URBAN MICROBIOLOGICAL ENVIRONMENT AND EPIDEMIC RISKS OF EMERGING INFECTIOUS DISEASES.
城市微生物环境变化与新发传染病流行风险监测研究。
- 批准号:
09470109 - 财政年份:1997
- 资助金额:
$ 4.03万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
マルチメディアによる在宅テレケアシステムの開発
多媒体家庭远程护理系统的开发
- 批准号:
08557031 - 财政年份:1996
- 资助金额:
$ 4.03万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
UNHEALTHY SEQUENCE IN THE EASTERN TOKYO.
东京东部的不健康序列。
- 批准号:
07457103 - 财政年份:1995
- 资助金额:
$ 4.03万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Alteration of metabolism and biotransformation of environmental chemicals in the liver cells due to changes in the intracellular level
由于细胞内水平的变化而改变肝细胞内环境化学物质的代谢和生物转化
- 批准号:
05454224 - 财政年份:1993
- 资助金额:
$ 4.03万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)
Development of an Experimental System by Using Perfused Organs to Study the Combined Effects of Environmental Factors
利用灌注器官开发实验系统来研究环境因素的综合影响
- 批准号:
01480204 - 财政年份:1989
- 资助金额:
$ 4.03万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)
What needed for home health care of the elderly in their residential environment.
居住环境中老年人的家庭保健需要什么。
- 批准号:
63300005 - 财政年份:1988
- 资助金额:
$ 4.03万 - 项目类别:
Grant-in-Aid for Co-operative Research (A)
Effects of Hypoxia and Environmental Agents on Renal Tubules with a Scope of Combined Effect
缺氧和环境因素对肾小管的影响及其联合作用范围
- 批准号:
61480163 - 财政年份:1986
- 资助金额:
$ 4.03万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)
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