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Elucidation of the mechanism on biological tissue injuries induced by shock waves

阐明冲击波引起生物组织损伤的机制

基本信息

批准号：
03454382
负责人：
KUWAHARA Masaaki
金额：
$ 4.03万
依托单位：
TOHOKU UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1991
资助国家：
日本
起止时间：
1991 至 1992
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-03454382/
关键词：
Shock Wave Biological Tissue Injury Cavitation Extracorporeal Shock Wave Lithotripsy Simulation of Shock Wave Focusing ESWL Cavitation Bubbles Fluid Flow Induced by Shock Wave

项目摘要

1)Elucidation of physical phenomena in the focal region of the focused shock waves concerning the mechanism of biological tissue injuries.Focusing process of shock waves inside water was observed under an ultrasound diagnostic system. It was revealed that the hyperechoic region was induced around the focal region, and it moved distally , then, disappeared gradualy with elapsed time. This observation indicated that cavitation bubbles was responsible for generation of the hyperechoic region, and a fluid flow was induced at the time, Gene-ration and behavior of the liquid flow was simulated numerically by computer, and the results of simulation indicated that a direction of the fluid flow was not only parallel, but also radial to that of shock wave propagation. Consequently, besides the cavitation phenomena, the fluid flow was assumend to be an important factor causing tissue injury. In addition, it was observed on ultrasonic images that cavitation developed in wide range through the shock wave propagating path, from the prefocal region to the postfocal region. Tissue injuries through the path of shock wave propagation was confirmed by animal experiment. From considering aforementioned results, a new safer lithotriptor equipped anti-miss-shot device was developed and clinically used.2)Real-time observation on the tissue injury in the in situ rabbit auricular vessels was performed using high-speed video camera. Results indicated that the artery was injured following the vein, and during that process vasoconstiriction and vasodilation developed, suggesting that shock waves effected on autonomic nerves. If compared to the injury of kidney vessls in the previous experiments, the auricular vessels were relatively resistive to the shock wavaes. Therefore, sensitivity to shock wave injury was assumed to be influenced by the acoustic condition in various organs.

1)阐明聚焦冲击波聚焦区的物理现象与生物组织损伤的机理。在超声诊断系统下观察了水中冲击波的聚焦过程。结果表明，高回声区是在病灶周围产生的，随着时间的推移，高回声区向远侧移动，然后逐渐消失。结果表明，空化气泡是产生强回声区的主要原因，在强回声区中产生了流体流动。利用计算机数值模拟了流体流动的产生和行为，结果表明，流体流动的方向不仅与激波传播方向平行，而且与激波传播方向呈径向。因此，除了空化现象外，流体流动也是造成组织损伤的重要因素。此外，在超声图像上观察到，空化通过冲击波传播路径从焦前区域到焦后区域在宽范围内发展。通过动物实验证实了冲击波传播途径对组织的损伤。基于上述研究结果，我们研制了一种新的安全性更高的碎石机防误射装置，并应用于临床。2）采用高速摄像机对兔耳血管原位组织损伤进行实时观察。结果表明，冲击波对植物神经的影响是先损伤动脉后损伤静脉，在此过程中血管发生收缩和舒张反应。与以往实验中肾血管的损伤相比，耳廓血管对冲击波的抵抗力较强。因此，对冲击波损伤的敏感性被认为受到各种器官中的声学条件的影响。