Protein Adsorption Tuned by Multivalent Ions (PATMI):Connecting Bulk to Interface Behaviour by Controlling Interactions

多价离子调节的蛋白质吸附 (PATMI):通过控制相互作用将体相与界面行为联系起来

基本信息

项目摘要

This proposal aims to employ the rich bulk phase behaviour of protein solutions including re-entrant condensation mediated by multivalent ions to elucidate the fundamentals of protein adsorption at interfaces beyond simple charge screening.This qualitatively new behaviour will be explored both at equilibrium (i.e. adsorption isotherms will be determined along with the equilibrium structures) and dynamically (and therefore prior to equilibrium, i.e. the adsorption kinetics will be investigated), with particular attention to clarify the role of surface-induced nucleation and its importance for protein crystallisation.We aim to connect the interface behaviour to the interactions controlled by multivalent ions and the bulk behaviour within the concept of ion-activated patches.We make use of our expertise in surface analysis techniques, such as ellipsometry, QCM-D, FTIRRAS/ATR and in particular neutron and X-ray scattering, which allow a detailed determination of the adsorbed layer structure at the molecular level.
本研究的目的是利用蛋白质溶液丰富的体相行为,包括多价离子介导的重入凝聚,来阐明蛋白质在界面吸附的基本原理,而不仅仅是简单的电荷屏蔽。(即吸附等温线将沿着平衡结构确定)和动态地(因此在平衡之前,即将研究吸附动力学),特别注意阐明表面诱导成核的作用及其对蛋白质结晶的重要性。我们的目标是将界面行为与多价离子控制的相互作用和离子概念内的本体行为联系起来。我们利用我们在表面分析技术方面的专业知识,如椭圆偏振法、QCM-D、FTIRRAS/ATR,特别是中子和X射线散射,可以在分子水平上详细确定吸附层结构。

项目成果

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Professor Dr. Frank Schreiber其他文献

Professor Dr. Frank Schreiber的其他文献

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{{ truncateString('Professor Dr. Frank Schreiber', 18)}}的其他基金

Exploring the limits of real-time studies of growth of molecular and hybrid systems
探索分子和混合系统生长实时研究的局限性
  • 批准号:
    419187842
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
    Research Grants
Static and dynamic properties of antibody proteins in solution - the effects of crowding and charge-tuning
溶液中抗体蛋白的静态和动态特性 - 拥挤和电荷调节的影响
  • 批准号:
    316738961
  • 财政年份:
    2016
  • 资助金额:
    --
  • 项目类别:
    Research Grants
Diffusion in protein solutions: the effect of crowding, temperature and charges
蛋白质溶液中的扩散:拥挤、温度和电荷的影响
  • 批准号:
    240526267
  • 财政年份:
    2013
  • 资助金额:
    --
  • 项目类别:
    Research Grants
In situ and real-time investigations of organic semiconductor film growth
有机半导体薄膜生长的原位实时研究
  • 批准号:
    99734980
  • 财政年份:
    2009
  • 资助金额:
    --
  • 项目类别:
    Research Grants
Two-Components Colloidal Solutions: Tuning the Interactions of Functionalized Nanoparticles with Proteins
双组分胶体溶液:调节功能化纳米粒子与蛋白质的相互作用
  • 批准号:
    123578767
  • 财政年份:
    2009
  • 资助金额:
    --
  • 项目类别:
    Research Grants
Röntgenstreuungsuntersuchungen an organisch-anorganischen Grenzflächen
有机-无机界面的X射线散射研究
  • 批准号:
    5304886
  • 财政年份:
    2001
  • 资助金额:
    --
  • 项目类别:
    Priority Programmes
Dynamics, kinetics and assembly of model intrinsically disordered proteins from a polymer physics perspective
从聚合物物理学的角度研究模型本质无序蛋白质的动力学、动力学和组装
  • 批准号:
    490662871
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
    Research Grants

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复杂流体中添加剂自组装、流变学和表面吸附的分子模拟
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