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Morphological analysis of organizational principles of neuronal connections in the mammalian central nervous system

哺乳动物中枢神经系统神经元连接组织原理的形态学分析

基本信息

批准号：
59480095
负责人：
MIZUNO Noboru
金额：
$ 4.03万
依托单位：
Kyoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1984
资助国家：
日本
起止时间：
1984 至 1986
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-59480095/
关键词：
Auditory system Basal ganglia Central nervous system Gustatory system Limbic system Neuropeptides Somatosensory system ニューロペプチド

项目摘要

1. Direct projections from the central amygdaloid nucleus to the spinal cord were found in the Japanese monkey by the retrograde horseradish peroxidase method.2. A retrograde and anterograde wheat germ agglutinated horseradish peroxidase study in the cat revealed that some neurons in the dorsal column nuclei and interpolar and caudal spinal trigeminal nuclei sent projection fibers to the dorsal and ventral cochlear nuclei.3. Neurotensin-like immunoreactivity was visualized in projection neurons in the striatum of the cat. Some of these neurons with neurotensin-like immunoreactivity were further indicated to contain enkephalin or gamma amino butyric acid.4. The thalamic taste are (ventromedial region in the parvicellular division of the posteromedial ventral nucleus of the thalamus) in the cat were found to send projection fibers not only to the taste area in the cerebral cortex (area 43) but also to the rostrodorsal part of the lateral amygdaloid nucleus, infralimbic cortex (area 25), and perirhinal cortical area (area 35).5. Cytochrome oxidase histochemistry revealed patchy patterns of the enzyme activity in transverse sections through the caudal part of the ventral subnucleus of the main sensory trigeminal nucleus, interpolar spinal trigeminal nucleus, and layer IV of the caudal spinal trigeminal nucleus in the cat. By the transganglionic transport method of horseradish peroxidase, the patterns were indicated to replicate the spacial array of the facial vibrissae.

1.用辣根过氧化物酶逆行追踪法在日本猴中发现杏仁中央核向脊髓的直接投射.用麦胚凝集辣根过氧化物酶逆行和顺行法研究猫耳蜗背柱核、三叉神经脊束极间核和尾侧核的神经元向耳蜗背侧核和腹侧核发出投射纤维.在猫纹状体投射神经元中可见神经降压素样免疫反应阳性，其中一些神经降压素样免疫反应阳性的神经元还含有脑啡肽或γ-氨基丁酸.猫的丘脑味觉区（丘脑腹后内侧核小细胞区的腹内侧区）不仅向大脑皮层的味觉区（43区）投射投射纤维，而且还向杏仁外侧核的吻背侧部、边缘下皮层（25区）和嗅周皮层（35区）投射纤维.细胞色素氧化酶组织化学显示斑片状的酶活性的横切面通过猫的三叉神经脊束核腹侧亚核的尾侧部分，极间三叉神经脊束核，和三叉神经脊束核尾侧IV层的辣根过氧化物酶的跨神经节运输方法，图案被指示复制的空间阵列的面部触须。