Neuronal connections of module structures in the brain

大脑模块结构的神经元连接

• 批准号: 02454113
• 负责人: MIZUNO Noboru
• 金额: $ 3.58万
• 依托单位: KYOTO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1992
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-02454113/
• 关键词: Glutamate; Receptor; Glutaminase; Striatum; Amygdala; Cerebral cortex; Cerebellum; Ventral tegmental area; 淡蒼球; 黒質; 上丘; 海馬台; ド-パミン; アセチルコリン; 神経ペプチド; グルタミナ-ゼ; 孤束核; 三叉神経感覚核; CGRP; P物質

1. In the rat striatum, glutaminase-like immunoreactivity was found in non-cholinergic neurons. Axon terminals containing glutaminase were observed with mosaic patterns; glutaminase immunoreactivity in neuropil was more marked in the "patches" than in the "matrix".2. In the neo- and mesocortex of the rat, glutaminase-like immunoreactivity was found in pyramidal cells, but not in most GABAergic, cholinergic and peptidergic nonpyramidal cells.3. Distributions of the mRNAs for metabotropic glutamate receptors, mGluRu and mG1uR2, were examined in the rat brain by in situ hybridization.4. The projections from the ventral tegumental area to the cerebellum in the rat were found to be segregated into the dopaminergic projections to the cerebellar cortex and the non-dopaminergic projections to the deep cerebeallr nuclei.5. The central amygdaloid nucleus of the cat was found to send projection fibers to the globus pallidus and substantia nigra pars compacta, possibly exerting limbic influences upon forebrain motor mechanisms.

1.在大鼠纹状体中，在非胆碱能神经元中发现了精氨酸酶样免疫反应。轴突终末内含有谷氨酰胺酶，呈马赛克状，神经元内谷氨酰胺酶免疫反应在“斑块”内较“基质”内明显.在大鼠的新皮质和中皮质，在锥体细胞中发现了γ-氨基丁酸酶样免疫反应阳性细胞，而在大多数GABA能、胆碱能和肽能非锥体细胞中未发现.原位杂交检测代谢型谷氨酸受体mGluR 1和mG 1uR 2 mRNA在大鼠脑内的分布.大鼠腹侧被盖区向小脑的投射分为向小脑皮质的多巴胺能投射和向大脑深核的非多巴胺能投射.猫中央杏仁核可向苍白球和黑质发出投射纤维，可能对前脑运动机制产生边缘系统影响。

项目成果

Ikai,Yoshiaki: "Dopamineroic and non-dopaminergic neurons in the ventral tegmental area of the rat project,respectively,to the cerebellar cortex and deep cerebellar nuclei" Neuroscience. 51. 719-728 (1992)

Ikai，Yoshiaki：“大鼠腹侧被盖区的多巴胺能和非多巴胺能神经元分别投射到小脑皮质和小脑深核”神经科学。

Shinonaga,Yasuhide: "Direct projections from the central amygdaloid nucleus to the globus pallidus and substantia nigra in the cat" Neuroscience. 51. 691-703 (1992)

Shinonaga，Yasuhide：“从中央杏仁核到猫的苍白球和黑质的直接投影”神经科学。

Nakano,Katsuma: "Topographical projections from the thalamus,subthalamic nucleus and pedunculopontine tegmental nucleus to the striatum in the Japanese monkey,Macaca fuscata" Brain Research. 537. 54-68 (1990)

Nakano，Katsuma：“日本猴（Macaca fuscata）从丘脑、底丘脑核和脚桥被盖核到纹状体的地形投影”大脑研究。

Shigemoto, Ryuichi: "Distribution of the mRNA for a metabo-tropic glutamate receptor (mGluR1) in the central nervous system: an in situ hybridization study in adult and develoing rat" J. comp. Neurol.322. 121-135 (1992)

Shigemoto, Ryuichi：“中枢神经系统中代谢型谷氨酸受体 (mGluR1) 的 mRNA 分布：成年和发育中大鼠的原位杂交研究”J. comp。

Shinonaga,Yasuhide: "Cholinergic projections from the globus pallidus to the lateral amygdaloid nucleus in the cat" Neurosci.Lett.131. 53-56 (1991)

Shinonaga，Yasuhide：“猫从苍白球到外侧杏仁核的胆碱能投射”Neurosci.Lett.131。