Simulation and Clinical Implication of Peripheral Circulation

外周循环的模拟及其临床意义

• 批准号: 61480273
• 负责人: SAKURAI Kenji
• 金额: $ 2.18万
• 依托单位: The Jikei University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1986
• 资助国家: 日本
• 起止时间: 1986 至 1987
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-61480273/
• 关键词: Peripheral Circulation; Simulation; Arterial Insufficiency; 血管弾性; 血管抵抗

Simulation and Clinical Implication of Peripheral CirculationArterial insufficiency due to stenosis or thrombosis is more often seen and treated in japan in recent years. An objective analysis and understanding of the arterial circulation seems to be a paramount importance in treating these patients. In this study, a computer program to simulate the arterial circulation was developed and non-traumatic ultrasonic apparatus to measure blood pressure and flow at several locations of the lower extremity were devised. These collected clinical informations and their computer simulation outputs were utilized for objective clinical assesment.Development of Simulation Model and Program: The arterial system of the lower extremity was chosen as a prototype. An electrical and mathematical model of the lower extremity circulation was constructed and a simulation program for the personal computer(PC9801) was developed by a three element circuit analog, where V is blood pressure, R is characteristic arterial impedance and C are capacitance of the vascular bed. Segmental blood pressure and flow parameter values were measured and recorded to data recorder. These measured pressure and flow wave forms were used to calculate the input impedance spectrum. The program was again evaluated by comparing clinical measurements and the flow pressure wave forms generated by computer.Clinical Implication: Datail and precise asseessment of the arterial circulation of the lower extremity, first by collecting the clinical informations using non-traumatic ultrasonic apparatus and then by subjecting the informations to the computer simulation program, would help predict and evaluate treatment results and patient's natural course. Effects of increased vascular resistance and ailed compliance due to diseases are well understood by computer graphics. Imaginary or expected results of a certain medication or operation are also shown by changing parameter-values in the simulation programs.

外周循环动脉狭窄或血栓形成不全的模拟及临床意义近年来在日本越来越常见和治疗。客观分析和了解动脉循环似乎是治疗这些患者的最重要的。在本研究中，我们开发了一个模拟动脉循环的计算机程序，并设计了非创伤性超声仪来测量下肢几个位置的血压和血流。这些收集的临床信息及其计算机模拟输出用于客观的临床评估。仿真模型和程序的开发：以下肢动脉系统为原型。建立了下肢循环的电学和数学模型，并采用V为血压，R为特征动脉阻抗，C为血管床电容的三元电路模拟方法，编制了个人计算机（PC9801）的仿真程序。测量节段血压和血流参数值并记录在数据记录仪上。这些测量的压力和流量波形被用来计算输入阻抗谱。通过比较临床测量结果和计算机生成的流量压力波形，再次对程序进行评估。临床意义：对下肢动脉循环进行详细、准确的评估，首先利用非创伤性超声仪器收集临床信息，然后将这些信息输入计算机模拟程序，有助于预测和评估治疗效果和患者的自然病程。由于疾病导致血管阻力增加和依从性不佳的影响可以通过计算机图形学很好地理解。通过改变模拟程序中的参数值，也可以显示某种药物或手术的想象或预期结果。

项目成果

桜井健司編・著: "外来における外科的ケアの実際" 医学書院, 345 (1986)

樱井健司编辑和撰写：“门诊环境中的外科护理实践” Igakushoin，345 (1986)

Atsushi Amemiya: Japanese Journal of Surgery. 17. 178-181 (1987)

Atsushi Amemiya：日本外科杂志。

Kazumasa,UMEZAWA, et al.: "Development of Electrical Conductive Carbon Knitted Vascular Prosthesis." Japanese Journal of Artificcial Organs. 16. 1505-1508 (1987)

Kazumasa，UMEZAWA 等人：“导电碳针织血管假体的开发”。

赤羽紀武: 人工臓器. 16. 1232-1235 (1987)

赤羽则武：人造器官。16. 1232-1235 (1987)

Toshiyuki,YODA, et al.: "Clinical Results of Lipo PGE1 for peripheral arterial insufficiency." Junkankika. 20. 159-167 (1986)

Toshiyuki,YODA 等人：“Lipo PGE1 治疗外周动脉供血不足的临床结果。”