The function of the ribbon structure of the Golgi apparatus in vertebrates

高尔基体带状结构在脊椎动物中的功能

• 批准号: DP160102394
• 负责人: Prof Paul Gleeson
• 金额: $ 33.05万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-08-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160102394
• 关键词: function; ribbon; structure; Golgi; apparatus

The aim of the project is to determine the function of the Golgi ribbon structure in higher order cell functions, including metabolism, cell cycle, and cell polarity in both cultured cells and whole organisms. Understanding of the functions of the Golgi has been restricted to the regulation of glycosylation and membrane transport. However, it is now recognised that the Golgi apparatus feeds into the wiring of a range of cellular networks in higher organisms such as cell polarisation, directed migration, metabolism and autophagy. Vertebrates have evolved mechanisms for joining individual Golgi stacks into a ribbon structure. The relevance of this ribbon structure remains a mystery. The project aims to answer this major question in cell biology.

该项目的目的是确定高尔基带结构在高级细胞功能中的功能，包括培养细胞和整个生物体中的代谢，细胞周期和细胞极性。对高尔基体功能的理解仅限于糖基化和膜转运的调节。然而，现在人们认识到，高尔基体在高等生物中参与了一系列细胞网络的布线，如细胞极化，定向迁移，代谢和自噬。脊椎动物已经进化出将单个高尔基体堆叠成带状结构的机制。这种带状结构的相关性仍然是一个谜。该项目旨在回答细胞生物学中的这个主要问题。