The structure and function of the trans-Golgi network: role of golgins and G proteins

跨高尔基体网络的结构和功能：高尔基蛋白和 G 蛋白的作用

• 批准号: DP1094717
• 负责人: Prof Paul Gleeson
• 金额: $ 22.99万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1094717
• 关键词: structure; function; trans; Golgi; network

This research will provide a better understanding of the secretory pathway of all eukaryotic cells, a process of broad biological and biomedical significance. It will also contribute to a better understanding of how a cell works, including how cell membranes are organization, how the transport processes of the cell are regulated and how proteins are targeted to their intracellular destination. Further, this work will utilize the frontier technology of RNA interference as a genetic tool to investigate functions of genes. By training post-graduate students and post-doctoral staff, it will contribute to the expertise of cell biology in Australia. International collaborations will enhance connections with overseas researchers.

这项研究将提供一个更好地了解所有真核细胞的分泌途径，广泛的生物学和生物医学意义的过程。 它还将有助于更好地了解细胞如何工作，包括细胞膜如何组织，细胞的运输过程如何调节以及蛋白质如何靶向其细胞内目的地。 此外，这项工作将利用RNA干扰的前沿技术作为研究基因功能的遗传工具。 通过培训研究生和博士后工作人员，它将有助于澳大利亚细胞生物学的专业知识。 国际合作将加强与海外研究人员的联系。