Intracellular trafficking and function of a recycling receptor which prolongs the serum half-life of novel therapeutic proteins

延长新型治疗蛋白血清半衰期的循环受体的细胞内运输和功能

• 批准号: LP130100531
• 负责人: Prof Paul Gleeson
• 金额: $ 35.56万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-12-20 至 2017-05-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP130100531
• 关键词: Intracellular; trafficking; function; recycling; receptor

The life span of recombinant engineered proteins for therapeutic use is a critical factor in their effectiveness, ease of clinical application and cost. This project will exploit interactions with a natural receptor, which prolongs the lifespan of serum proteins, to enhance survival of therapeutic engineered proteins.

用于治疗用途的重组工程蛋白的寿命是其有效性、临床应用的容易性和成本的关键因素。该项目将利用与天然受体的相互作用，延长血清蛋白的寿命，以提高治疗性工程蛋白的存活率。