Dissecting retrograde endosome- to-Golgi transport pathways relevant to development, cell function and disease
Dissecting retrograde endosome- to-Golgi transport pathways relevant to development, cell function and disease
批准号:
nhmrc : 566728
负责人:
Prof Paul Gleeson
金额:
$36.36万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2009
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2009-01-01 至 2012-12-31
中文摘要
细胞内分子通过膜转运过程的运动对正常细胞功能至关重要,也被细菌利用来促进感染。将输入途径连接到输出途径的途径对于大量蛋白质的功能是必不可少的,然而这种连接途径的特征很差。本研究将定义这种运输途径的机制,这将提供调节生物过程和细胞毒性的能力。
英文摘要
Movement of molecules within cells by a process known as membrane transport is critical for normal cell function and also exploited by bacteria to promote infection. The pathway that connects the import pathway to the export pathway is essential for the function of a large number of proteins, however this connecting pathway is poorly characterised. This study will define the machinery of this trafficking pathway, which will provide the ability to modulate biological processes and cytotoxicity.
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