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Dissecting retrograde endosome- to-Golgi transport pathways relevant to development, cell function and disease

Dissecting retrograde endosome- to-Golgi transport pathways relevant to development, cell function and disease
剖析与发育、细胞功能和疾病相关的逆行内体到高尔基体的转运途径
批准号:
nhmrc : 566728
负责人:
Prof Paul Gleeson
金额:
$36.36万
依托单位:
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2009
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2009-01-01 至 2012-12-31

项目摘要

项目成果

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中文摘要
翻译
通过被称为膜运输的过程在细胞内移动分子对正常细胞功能至关重要,也被细菌利用来促进感染。连接输入途径和输出途径的途径对于大量蛋白质的功能是必不可少的,然而,这种连接途径的特征并不理想。这项研究将确定这一转运途径的机制,它将提供调节生物过程和细胞毒性的能力。
英文摘要
Movement of molecules within cells by a process known as membrane transport is critical for normal cell function and also exploited by bacteria to promote infection. The pathway that connects the import pathway to the export pathway is essential for the function of a large number of proteins, however this connecting pathway is poorly characterised. This study will define the machinery of this trafficking pathway, which will provide the ability to modulate biological processes and cytotoxicity.
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The cell biology of the albumin-FcRn receptor recycling system
  • 批准号:
    LP160101373
  • 项目类别:
    Linkage Projects
  • 资助金额:
    $32.91万
  • 财政年份:
    2017
  • 负责人:
    Prof Paul Gleeson
  • 依托单位:
The function of the ribbon structure of the Golgi apparatus in vertebrates
  • 批准号:
    DP160102394
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $33.05万
  • 财政年份:
    2016
  • 负责人:
    Prof Paul Gleeson
  • 依托单位:
Membrane trafficking of BACE1 and amyloid precursor protein in primary neurons and the production of Abeta amyloid peptides
  • 批准号:
    nhmrc : GNT1082600
  • 项目类别:
    Project Grants
  • 资助金额:
    $68.38万
  • 财政年份:
    2015
  • 负责人:
    Prof Paul Gleeson
  • 依托单位:
Membrane trafficking of BACE1 and amyloid precursor protein in primary neurons and the production of Abeta amyloid peptides
  • 批准号:
    nhmrc : 1082600
  • 项目类别:
    Project Grants
  • 资助金额:
    $47.08万
  • 财政年份:
    2015
  • 负责人:
    Prof Paul Gleeson
  • 依托单位:
国内基金
海外基金
细胞运动中微管网络有序分布的调控机制
Rab7酶和TBC1d5调节Retromer运输的机制研究
  • 批准号:
    31671477
  • 项目类别:
    面上项目
  • 资助金额:
    25.0万元
  • 批准年份:
    2016
  • 负责人:
    贾大
  • 依托单位: