Dissecting retrograde endosome- to-Golgi transport pathways relevant to development, cell function and disease

剖析与发育、细胞功能和疾病相关的逆行内体到高尔基体的转运途径

• 批准号: nhmrc : 566728
• 负责人: Prof Paul Gleeson
• 金额: $ 36.36万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dissecting-retrograde-endosome-function-disease/76653
• 关键词: Dissecting; retrograde; endosome; Golgi; transport

Movement of molecules within cells by a process known as membrane transport is critical for normal cell function and also exploited by bacteria to promote infection. The pathway that connects the import pathway to the export pathway is essential for the function of a large number of proteins, however this connecting pathway is poorly characterised. This study will define the machinery of this trafficking pathway, which will provide the ability to modulate biological processes and cytotoxicity.

通过被称为膜运输的过程在细胞内移动分子对正常细胞功能至关重要，也被细菌利用来促进感染。连接输入途径和输出途径的途径对于大量蛋白质的功能是必不可少的，然而，这种连接途径的特征并不理想。这项研究将确定这一转运途径的机制，它将提供调节生物过程和细胞毒性的能力。