Membrane trafficking of the ?-secretase, BACE1, and the generation of Alzheimer's disease A? amyloid peptides

β-分泌酶、BACE1 的膜运输和阿尔茨海默病 A 的产生？

• 批准号: nhmrc : 1024561
• 负责人: Prof Paul Gleeson
• 金额: $ 31.05万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/membrane-trafficking-secretase-amyloid-peptides/110361
• 关键词: Membrane; trafficking; secretase; BACE1; generation

Alzheimer’s disease results from the production of toxic neuropeptides by the action of an enzyme called BACE. The generation of toxic peptides requires the movement or trafficking of BACE between different cell compartments. This research will reveal the molecular machinery of the BACE transport pathway. This new knowledge will provide a strategy to develop drugs to inhibit BACE activity and the production of the toxic peptide, which would be of significant benefit to patients and families.

阿尔茨海默氏症是由于一种名为BACE的酶的作用而产生的有毒神经肽造成的。有毒多肽的产生需要BACE在不同的细胞间移动或运输。本研究将揭示BACE转运途径的分子机制。这一新知识将为开发抑制BACE活性和毒肽产生的药物提供一种策略，这将对患者和家庭产生重大好处。