Membrane trafficking of BACE1 and amyloid precursor protein in primary neurons and the production of Abeta amyloid peptides

原代神经元中 BACE1 和淀粉样前体蛋白的膜运输以及 Abeta 淀粉样肽的产生

• 批准号: nhmrc : 1082600
• 负责人: Prof Paul Gleeson
• 金额: $ 47.08万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/membrane-trafficking-bace1-amyloid-peptides/518890
• 关键词: Membrane; trafficking; BACE1; amyloid; precursor

The development of Alzheimer’s disease results from the generation of toxic peptides by the cleavage of a membrane protein by an enzyme called BACE. A key feature of which regulates the generation of toxic peptides involves the movement of BACE between compartments in the cell by a process known as membrane transport. Our recent work has identified the itinerary of BACE in the cell. The studies here will reveal the molecular machinery of the BACE pathway in neurons. This fundamental informati

阿尔茨海默病的发展是由于一种名为BACE的酶裂解一种膜蛋白而产生的有毒多肽。调节有毒多肽产生的一个关键特征是BACE通过一种被称为膜转运的过程在细胞内的隔室之间移动。我们最近的工作已经确定了BACE在细胞内的行程。这些研究将揭示BACE通路在神经元中的分子机制。这些基本信息