Membrane trafficking of BACE1 and amyloid precursor protein in primary neurons and the production of Abeta amyloid peptides
Membrane trafficking of BACE1 and amyloid precursor protein in primary neurons and the production of Abeta amyloid peptides
批准号:
nhmrc : 1082600
负责人:
Prof Paul Gleeson
金额:
$47.08万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2015
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2015-01-01 至 2018-12-31
中文摘要
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英文摘要
The development of Alzheimer’s disease results from the generation of toxic peptides by the cleavage of a membrane protein by an enzyme called BACE. A key feature of which regulates the generation of toxic peptides involves the movement of BACE between compartments in the cell by a process known as membrane transport. Our recent work has identified the itinerary of BACE in the cell. The studies here will reveal the molecular machinery of the BACE pathway in neurons. This fundamental informati
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依托单位:
国内基金
海外基金
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