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Basic and clinical research of Gd-DTPA enhanced MR imaging and analysis of cardiac function in the patients with myocardial infarction

心肌梗死患者Gd-DTPA增强MR成像及心功能分析的基础与临床研究

基本信息

批准号：
04670672
负责人：
MATSUNAGA Naofumi
金额：
$ 1.34万
依托单位：
Nagasaki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1992
资助国家：
日本
起止时间：
1992 至 1993
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04670672/
关键词：
MRI Myocardial infarction Contrast media Gd-DTPA Spin-echo image

项目摘要

PURPOSE : We assessed the effectiveness of gadopentetate dimeglumine injection in enhancing signal-intensity differences between normal and infarcted myocardium on ECG-gated spin-echo T1-weighted images. MATERIALS AND METHODS : The 84 MR examinations of 66 patients 14-350 days after acute myocardial infarction were obtained before and after administration of 0.1mmol/kg of Gd-DTPA (gadopentetate dimeglumine). Image acquisitions were repeated every 5 min with 3 minutes gap for up to 26 min in three sequential scans in 58 patients, and for up to 42 min in five sequential scans in ten patients. Time-dependent changes in signal intensity ratio between infarcted and normal myocardium (infarct/normal ratio) and serial changes of infarct/normal ratio in different stages were measured. RESULTS : Contrast enhancement of the infarcted myocardium was observed in 66 of 84 patients (78.6%). Infarct/normal ratio was increased at the initial acquisition during 5-10 minutes, reached the plateau at 13-18 minutes of acquisition, 21-26 minutes, and 29-34 minutes, and the augmented ratios gradually declined at 37-42 minutes. Contrast enhancement of the infarcted myocardium was observed in 9 of 10 (90.0%) imaged at 1-3 weeks after acute myocardial infarction, in 16 of 19 examinations (84.2%) at 4-6 weeks, in 24 of 29 (82.8%) at 7-9 weeks, in 16 of 21 (76.2%) at 10-32 weeks, and in none of 5 (0%) at 33-50 weeks. CONCLUSION : These results suggest that Gd-DTPA can improve MR visualization and detection of myocardial infarction, and facilitates the process of the repair of the myocardial infarction.

目的：在心电门控自旋回波T1加权像上，我们评价了注射加多巴喷妥钠地葡胺增强正常心肌和梗死心肌信号强度差异的有效性。材料和方法：66例急性心肌梗死后14~350d的患者，分别于注射Gd-DTPA(Gd-DTPA)0.1 mmol/kg前后进行84次MR检查。对58例患者进行3次连续扫描，每隔5分钟重复图像采集，间隔3分钟，最多26分钟；对10例患者进行5次连续扫描，最多42分钟。测定心肌梗死与正常心肌信号强度比(梗死灶/正常值)的时间依赖性变化及不同阶段梗死灶/正常值的动态变化。结果：84例患者中66例(78.6%)心肌梗死灶增强。心肌梗死/正常比值在5~10min开始升高，13~18min、21~26min、29~34min达到平台期，37~42min逐渐下降。急性心肌梗死后1~3周9例(90.0%)，4~6周16例(84.2%)，7~9周24例(82.8%)，10~32周16例(76.2%)，33~50周5例(0%)。结论：Gd-DTPA可提高心肌梗死的MR显示和检出，有利于心肌梗死的修复。