Neurotranplantation and deep brain electrical stimulation for Parkinson's disease

神经移植和深部脑电刺激治疗帕金森病

• 批准号: 11671380
• 负责人: ITAKURA Toru
• 金额: $ 0.9万
• 依托单位: Wakayama Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11671380/
• 关键词: Parkinson disease; transplant; sympathetic ganglion; 細胞移植

In the present research project we have investigated effect of transplantation of autologous sympathetic ganglion into the brain on parkinsonian symptoms. We also studied clinical research for deep brain stimulation of the globus pallidus in Parkinson patients.Fifty percent of the patients receiving transplantation of sympathetic ganglion showed improvement of parkinsonian symptoms such as gait disturbance and bradykinesia. However, the patients did not show improvement of muscle rigidity and tremor after transplantation. These effects continued up to 6 years after transplantation.Chronic electrical stimulation of the globus pallidus was performed in 20 patients with Parkinson disease. About 60% of the patients showed improvement of Parkinson symptoms, especially drug-induced dyskinesia, muscle rigidity and bradykinesia. Neurotransmitters such as GABA, dopamine and other catecholamines were measured during electrical stimulation of the globus pallidus, which showed elevation of GABA in the ventricular fluid 1hr after stimulation.These studies clearly demonstrated the effects of transplantation and deep brain stimulation on symptoms in patients with Parkinson disease.

在本研究项目中，我们研究了自体交感神经节脑内移植对帕金森病症状的影响。我们还研究了帕金森病患者苍白球脑深部电刺激的临床研究，接受交感神经节移植的患者中有50%的患者表现出帕金森病症状的改善，如步态障碍和运动迟缓。然而，移植后患者的肌肉僵硬和震颤没有改善。对20例帕金森病患者进行了苍白球慢性电刺激。约60%的患者表现出帕金森症状的改善，尤其是药物引起的运动障碍，肌肉僵硬和运动迟缓。在电刺激苍白球期间测量神经递质如GABA、多巴胺和其他儿茶酚胺，其显示刺激后1小时脑室液中GABA升高。这些研究清楚地证明了移植和脑深部刺激对帕金森病患者症状的影响。

项目成果

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Nakao N,Yokote H,Nakai K,Itakura T: "Promotion of survival and regeneration of nigral dopamine neurons in-a rat model of Parkinson's disease"J Neurosurg. 92. 659-670 (2000)

Nakao N、Yokote H、Nakai K、Itakura T：“促进帕金森病大鼠模型中黑质多巴胺神经元的存活和再生”J Neurosurg。

板倉徹 前田敏博 編著: "大脳辺縁系"ブレーン出版. 143 (1999)

Toru Itakura 和 Toshihiro Maeda（编辑）：“边缘系统”Brain Publishing 143（1999）。

Nakao N, Kakishita K,, Uematsu Y, Nakai K, Itakura T: "Clinical Effects and mechanism of autologous thoracic ganglion transplant for Parkinson disease."Nouge. 30. 56-57 (2000)

Nakao N、Kakishita K、Uematsu Y、Nakai K、Itakura T：“自体胸神经节移植治疗帕金森病的临床效果和机制。”Nouge。

Nakao N, Itakura T: "Fetal tissue transplants in animal models of Huntington's disease : the effects on damaged neuronal circuitry and behavioral deficits."Prog Neurobiol. 61. 313-338 (2000)

Nakao N、Itakura T：“亨廷顿病动物模型中的胎儿组织移植：对受损神经元回路和行为缺陷的影响。”Prog Neurobiol。