Behavioral and neuropharmacological study on neural plasticity induced by neural transplantation or L-DOPA therapy

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A study was carried out to examine the effects of acute and chronic L-DOPA treatment on the distribution of the immediate-early gene(IEG) proteins(FosB, c-Fos, and Zif268) in forebrain regions in a unilateral 6-hydroxydopamine(6-OHDA) rat model of Parkinson's disease. During a course of chronic L-DOPA treatment, rats with a 6-OHDA lesion developed abnormal involuntary movements. Compared with the rats in the acute L-DOPA treatment group, those in the chronic treatment group had significantly more FosB-immunopositive cells in the anterior cingulate(Cg) and the dorsolateral caudate-putamen ipsilateral to the lesion. In summary, differential expression of three IEG proteins was observed in the forebrain regions during a course of chronic L-DOPA treatment of 6-OHDA-treated hemiparkinsonian rats.