Pharmacology, physiology and clinical application of pregnancy-induced analgesia

妊娠镇痛的药理学、生理学及临床应用

• 批准号: 06671544
• 负责人: IWASAKI Hiroshi
• 金额: $ 0.96万
• 依托单位: SAPPORO MEDICAL UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06671544/
• 关键词: pregnancy; endogenous analgesia; calcium channel blocker; カルシウムイオンチャンネル拮抗薬

This is one of serires of studies to examine the physiology of pregnacy-induced analgesia in rats. The main purpose of this study was to examine the effects of 1-type calcium channel blockers on pregnancy-induced analgesia.(1) This study was designed to investigate the effects of the intrathecal calcium channel blocker, verapamil, on the spinal anesthesia from lidacaine and tetracaine. Male Sprague-Dawley rats were chronically implanted with lumbar intrathecal catheters. Tail flick (TF) and mechanical paw pressure (MPP) tests were used to assess thermal and mechanical nociceptive threshold, respectively. Motor function was assessed using a modified Langerman's scale. Intrathecal lidocaine of tetracaine alone showed the prolongation of TF latency, the increase of MPP threshold, and the increase in motor function scale in a time-and dose-dependent manner. Although intrathecal verapamil alone demonstrated neither sensory nor motor block), the combination of lidocaine or tetracaine and ver … More apamil produced the more potent and prolonged antinociception and motor block when compared with local anesthetics alone. (2) We have studied the effects of three different types of calcium channel blockers (verapamil, diltiazem, and nicardipine) on local lidocaine sensory block. Standard tail flick (TF) test was employed to quantify the duration and dgree of local lidocaine-induced conduction block in rats. After obtaining baseline TF test, two 100mug of 0.3% lidocaine alone, a combination of verapamil, diltiazem, or nicardipine. and a large dose of calcium channel blockers were injected on opposite sites of the tail base. Coadministration of lidocaine and three doses of 1-type calcum channel blockers significant increases of antinociception at the level of the peripheral nerve. (3) The study was designed to examine the intrathecally administered calcium channel blocker, verapamil, on pregnancy-induced analgesia inrats. To assess thermal nociceptive threshold, tail flick test was emolyed. In pregnant rats, a significant increase in TF was demonstrated on late pregnancy. Intrathecally administered verapamil produced a significant prolongation of TF late in pregnancy. Less

这是一个系列的研究，以检查生理学的镇痛作用在大鼠。本研究的主要目的是研究1型钙通道阻滞剂对妊娠镇痛的影响。(1)本研究旨在观察鞘内注射钙通道阻滞剂维拉帕米对利多卡因和丁卡因腰麻的影响。雄性Sprague-Dawley大鼠长期植入腰椎鞘内导管。采用甩尾（TF）和机械爪压（MPP）试验分别测定热痛阈和机械痛阈。使用改良的Langerman量表评估运动功能。鞘内注射利多卡因或丁卡因均能使TF潜伏期延长，MPP阈值增加，运动功能评分增加，并呈时间和剂量依赖性。尽管鞘内单独注射维拉帕米既不表现出感觉阻滞也不表现出运动阻滞，但利多卡因或丁卡因与维拉帕米的联合应用， ...更多信息 当与单独的局部麻醉剂相比时，Apamil产生更有效和延长的抗伤害感受和运动阻滞。(2)我们研究了三种不同类型的钙通道阻滞剂（维拉帕米、地尔硫卓和尼卡地平）对局部利多卡因感觉阻滞的影响。采用标准甩尾试验（TF）测定利多卡因引起的大鼠局部传导阻滞的持续时间和程度。在获得基线TF测试后，两个100 μ g的0.3%利多卡因单独，维拉帕米，地尔硫卓或尼卡地平的组合。并在尾基部的相对部位注射大剂量的钙通道阻断剂。同时给予利多卡因和三种剂量的1型钙通道阻滞剂显著增加了外周神经水平的抗伤害性感受。(3)本研究旨在观察鞘内注射钙通道阻滞剂维拉帕米对大鼠妊娠镇痛的影响。采用甩尾试验测定热痛阈。在妊娠大鼠中，TF在妊娠晚期显著增加。鞘内注射维拉帕米在妊娠后期产生显著的TF延长。少

项目成果

Iwasaki H,Ohomori H,Omote K,Kawamata M,Sumita S,Yamauchi M,Namiki A.: "Potentiation of local lignocaine-induced sensory block by calcium channel blockers in rats.(in press.)" British Journal of Anaesthesia 199. 76.

Iwasaki H，Ohomori H，Omote K，Kawamata M，Sumita S，Yamauchi M，Namiki A.：“钙通道阻滞剂对大鼠局部利多卡因诱导的感觉阻滞的增强作用。（正在印刷中）”英国麻醉杂志 199。

Omotek, Iwasaki H. et al.: "Spinal antinoc ceptive action of an N-type voltage dependent calcium channel blecker and the syneigishc inferection" Anestbeclogy. 84(in press). (1996)

Omotek、Iwasaki H. 等人：“N 型电压依赖性钙通道阻断剂的脊髓抗痛感受作用和粘液感染”Anestbeclogy。

李潤子,岩崎寛他.: "妊娠に伴う内因性鎮痛に対するカルシウムチャンネル拮抗薬ベラパミルくも膜下投与の効果" Journal of Oneitheia. 9. A156 (1995)

Junko Lee、Hiroshi Iwasaki 等人：“鞘内施用钙通道拮抗剂维拉帕米对妊娠相关内源性镇痛的影响”Journal of Oneitheia 9. A156 (1995)。

Iwasaki H. et al.: "Potentiation of local lignocaine-induced sensory block by calcium channel blockers in rats." British Journal of Anaestbesia. 76(in press). (1996)

Iwasaki H. 等人：“钙通道阻滞剂对大鼠局部利多卡因诱导的感觉阻滞的增强作用。”

Iwasaki,H.et al: "Potentiation of local lignocaine sensory block by calcium channel blockers in rat" British Journal of Anaesthesia. 76(in press). (1996)

Iwasaki,H.等人：“钙通道阻滞剂对大鼠局部利多卡因感觉阻滞的增强”英国麻醉杂志。