RP2: Transfer from goal-directed behavior to stimulus-response habits and its modulation by acute stress in gaming disorder and buying-shopping disorder

RP2：从目标导向行为到刺激反应习惯的转变及其在游戏障碍和购买购物障碍中的急性压力的调节

• 批准号: 444977161
• 负责人: Professorin Dr. Astrid Müller
• 金额: --
• 依托单位: Lehrstuhl für Klinische Psychologie und Psychotherapie
• 依托单位国家: 德国
• 项目类别: Research Units
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/444977161?language=en
• 关键词: RP2; Transfer; goal; directed; behavior

The ability of conditioned stimuli to affect instrumental responding is a robust finding from animal as well as human research and is considered a key factor for the development and maintenance of addictive behaviors. In Internet use disorders, Pavlovian conditioning processes are thought to intensify motivational responses, which can activate instrumental reward seeking. However, there is very limited knowledge on the impact of conditioned cues on instrumental responding and of factors that affect these processes (e.g. acute stress) in individuals with risky or problematic use of specific Internet applications. While there is evidence that acute stress may trigger relapse in addictions, no study to date has investigated the effect of acute stress on the impact of conditioned cues on instrumental responding in individuals at risk for Internet use disorders. The aim of this project is to investigate the impact of conditioned stimuli on instrumental responding and possible effects of acute stress in early stages of gaming disorder and buying-shopping disorder. The project will include four groups (each with 64 participants): individuals with 1) risky use of games, 2) risky use of shopping applications, 3) non-problematic use of games, 4) non-problematic use of shopping applications. After completion of the diagnostics including the experimental and neuropsychological tasks of the core battery, a Pavlovian-Instrumental-Transfer (PIT) paradigm with stimuli and rewards related to gaming or buying-shopping will be used. In the Pavlovian training phase, two neutral stimuli will be paired either with gaming- or with buying-shopping stimuli. In the second phase, participants learn to perform different key presses to achieve gaming- or buying-shopping-related rewards. In the transfer phase, the conditioned stimuli from the Pavlovian training phase will be presented while the instrumental responses can be performed as before. An outcome devaluation will be implemented after the first half of the transfer phase. The role of acute stress will be investigated using the standardized Trier Social Stress Test, which will be administered after acquisition of the conditioned responses and learning of instrumental behavior. Reward expectancy ratings and attention allocation to the different experimental stimuli assessed with an eye-tracker will indicate conditioned responses while response choice and response rate indicate instrumental behavior. RP2 has strong synergies with RP3 and RP6, which will also investigate facets of cue reactivity. Furthermore, RP2 is connected to RP4, which will also address cue reactivity and acute stress. There are also synergies between RP2 and RP5, as both projects will investigate buying-shopping disorder and effects of acute stress.

条件刺激影响工具反应的能力是动物和人类研究的一个强有力的发现，被认为是成瘾行为发展和维持的关键因素。在互联网使用障碍中，巴甫洛夫条件反射过程被认为会加强动机反应，从而激活工具性奖励寻求。然而，有非常有限的知识的影响，条件线索的工具响应和影响这些过程的因素（如急性应激）在个人的风险或有问题的使用特定的互联网应用程序。虽然有证据表明，急性应激可能会引发成瘾复发，但迄今为止还没有研究调查急性应激对网络使用障碍风险个体的条件线索对工具性反应的影响。本研究的目的是探讨条件刺激对工具反应的影响，以及急性应激在游戏障碍和购物障碍早期阶段的可能作用。该项目将包括四组（每组64名参与者）：1）有风险使用游戏的个人，2）有风险使用购物应用程序的个人，3）无问题使用游戏的个人，4）无问题使用购物应用程序的个人。在完成诊断（包括核心电池的实验和神经心理学任务）后，将使用具有与游戏或购买购物相关的刺激和奖励的巴甫洛夫-工具-转移（PIT）范式。在巴甫洛夫训练阶段，两个中性刺激将与游戏或购物刺激配对。在第二阶段，参与者学习执行不同的按键，以获得游戏或购买购物相关的奖励。在迁移阶段，来自巴甫洛夫训练阶段的条件刺激将被呈现，而工具性反应可以像以前一样执行。结果贬值将在转移阶段的前半部分之后实施。急性应激的作用将使用标准化的特里尔社会应激测试进行研究，该测试将在获得条件反应和学习工具性行为后进行。用眼动仪对不同实验刺激的奖赏期望等级和注意分配表明条件反应，而反应选择和反应率表明工具性行为。RP 2与RP 3和RP 6具有很强的协同作用，这也将研究线索反应性的各个方面。此外，RP 2连接到RP 4，这也将解决线索反应性和急性应激。RP 2和RP 5之间也有协同作用，因为这两个项目都将研究购物障碍和急性压力的影响。