RP4: Cue reactivity in gaming disorder and pornography-use disorder: Behavioral and neural correlates and effects of acute stress

RP4：游戏障碍和色情使用障碍的提示反应：行为和神经相关性以及急性压力的影响

• 批准号: 444977283
• 负责人: Professor Dr. Matthias Brand
• 金额: --
• 依托单位: Klinik für Psychosomatische Medizin und Psychotherapie
• 依托单位国家: 德国
• 项目类别: Research Units
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/444977283?language=en
• 关键词: RP4; Cue; reactivity; gaming; disorder

Cue reactivity and craving are core concepts in research on substance use disorders and addictive behaviors. Deficits in executive functions and decision making have also been considered as playing an important role in addictive behaviors. The association between acute stress and addictive behaviors may be moderated by executive functions. Gaming disorder has been included in the ICD-11 as a disorder due to addictive behaviors. Pornography use disorder may be considered as a subcomponent of compulsive sexual behavior disorder, which has been included in the ICD-11. Many authors, however, rather see parallels between the specific problems in controlling the use of pornography and addictive behaviors, suggesting that pornography use disorder may be considered as subtype of Internet use disorders, comparable to gaming disorder. Neuroimaging studies on cue reactivity and craving in gaming disorder and pornography use disorder have shown activities in the ventral striatum and further structures involved in fronto-striatal loops. To date, there are no studies which systematically examined neural and behavioral correlates of cue reactivity and craving in gaming disorder compared to pornography use disorder. It is important to address this contrast given that pornography-related stimuli may be considered as natural rewards, compared to gaming-related stimuli, which may be considered as secondary reinforcers. This project aims at investigating 1) behavioral and neural correlates of cue reactivity and craving in gaming disorder compared to pornography use disorder, 2) the effects of acute stress on cue reactivity and craving, and 3) interactions between cue reactivity and craving, acute stress, and measures of executive functions and inhibitory control. The project will include five groups (each with 52 male participants): individuals with 1) gaming disorder, 2) risky use of games, 3) pornography use disorder, 4) risky use of pornography, and 5) control participants, who use both games and pornography non-problematically. The study will consist of three parts. At t1, the intensive diagnostics will be conducted including the experimental and neuropsychological tasks of the core battery. In the second part of t1, participants will be randomly assigned to either the stress condition of the Trier Social Stress Test or the control group and will perform a cue reactivity paradigm and a decision-making task with addiction-related pictures. At t2, the fMRI experiment (with 34 participants of each group) with a modified cue reactivity paradigm will be conducted. RP4 is strongly linked to RP2, RP3, and RP6, which will also investigate facets of cue reactivity. Moreover, there are links between RP4 and RP7, which will address inhibitory control and executive functions, and RP4 and RP5, which will examine effects of stress on cue reactivity.

提示反应性和渴望是有关物质使用障碍和成瘾行为研究的核心概念。行政职能和决策的缺陷也被认为是在成瘾行为中起着重要作用。急性压力和成瘾行为之间的关联可能会受到执行功能的调节。由于上瘾的行为，游戏障碍已被包括在ICD-11中作为一种疾病。色情使用障碍可能被认为是强迫性行为障碍的子部分，该障碍已包括在ICD-11中。但是，许多作者相反，在控制色情制图和上瘾行为的特定问题之间存在相似之处，这表明色情使用障碍可能被视为互联网使用障碍的亚型，与游戏障碍相当。关于游戏障碍和色情使用障碍中提示反应性和渴望的神经影像学研究表明，在腹侧纹状体和额叶纹状体环中涉及的其他结构中的活动。迄今为止，与色情使用障碍相比，尚无研究的研究对游戏障碍的神经和行为相关性。考虑到与游戏相关的刺激相比，与色情相关的刺激可能被认为是自然的奖励，这一点很重要，这可能被认为是次要增强剂。该项目的目的是研究1）与色情使用障碍相比，游戏障碍中提示反应性和渴望的行为和神经相关性，2）急性应力对提示反应性和渴望的影响，以及3）提示反应性和渴望，急性应激，急性压力以及执行功能和抑制性控制的措施之间的相互作用。该项目将包括五个小组（每个人都有52名男性参与者）：患有1）游戏障碍的人，2）风险使用游戏，3）色情使用障碍，4）危险使用色情，以及5）控制参与者，他们同时使用游戏和色情制图非问题。该研究将由三个部分组成。在T1，将进行密集的诊断，包括核心电池的实验和神经心理学任务。在T1的第二部分中，参与者将被随机分配到TRIER社会压力测试或对照组的应力状况，并将执行提示反应性范式和与成瘾相关图片的决策任务。在T2时，将进行fMRI实验（每组34名参与者），具有改进的提示反应性范例。 RP4与RP2，RP3和RP6密切相关，这也将研究提示反应性的方面。此外，RP4和RP7之间存在联系，它将解决抑制性控制和执行功能，以及RP4和RP5，这将检查压力对提示反应性的影响。