Mechanisms of the development of neuronal cell community in the central nervous system

中枢神经系统神经细胞群落的发育机制

• 批准号: 19200031
• 负责人: NAKAJIMA Kazunori
• 金额: $ 23.71万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19200031/
• 关键词: 大脳皮質; 発生・分化; 神経科学; 脳・神経; 細胞移動; 神経細胞移動; 辺縁帯; IPA; カルシウム; 樹状突起形成

We have focused on the migration process of neocortical neurons and identified many genes that are preferentially expressed in cells just beneath the marginal zone. In addition, we have identified functions of several genes in layer formation and migrating cell dynamics. We have also found the differences of migratory behavior between direct progeny of apical progenitors and basal progenitors in the developing neocortex. The former stay above the ventricular zone for almost 1 day, where we named the multipolar cell accumulation zone (MAZ).

我们专注于新皮质神经元的迁移过程，并确定了许多在边缘带下方的细胞中优先表达的基因。此外，我们还确定了几个基因在成层和迁移细胞动力学中的功能。我们还发现在发育中的新皮质中，顶端祖细胞和基底层祖细胞的直接后代的迁移行为存在差异。前者在脑室区上方停留近1天，我们称之为多极细胞聚集区(MAZ)。

项目成果

細胞間接着による大脳皮質層形成機構の解析

细胞间粘附的大脑皮质层形成机制分析

• 发表时间: 2007
• 作者: Yasutake Takahashi;Teruyasu Kawamata;Minoru Asada;and Mario Negrello;大石 康二
• 通讯作者: 大石 康二

Cdk5 is required for multipolar-to-bipolar transition during radial neuronal migration and proper dendrite development of pyramidal neurons in the cerebral cortex

• DOI: 10.1242/dev.02854
• 发表时间: 2007-06-15
• 期刊: DEVELOPMENT
• 影响因子: 4.6
• 作者: Ohshima, Toshio;Hirasawa, Motoyuki;Mikoshiba, Katsuhiko
• 通讯作者: Mikoshiba, Katsuhiko

Time constraints and positional cues in the developing cerebellum regulate Purkinje cell placement in the cortical architecture

• DOI: 10.1016/j.ydbio.2008.02.005
• 发表时间: 2008-05-01
• 期刊: DEVELOPMENTAL BIOLOGY
• 影响因子: 2.7
• 作者: Carletti, Barbara;Williams, Ian Martin;Rossi, Ferdinando
• 通讯作者: Rossi, Ferdinando

発生期大脳皮質の皮質板上層部で優位に発現する分子の検索と機能解析

主要在发育中的大脑皮层的上皮层中表达的分子的搜索和功能分析

• 发表时间: 2007
• 作者: Unzai;T.;Fujiyama;F.;Kaneko;T;刀川 夏詩子
• 通讯作者: 刀川 夏詩子

Ectopic Reelin Induces Neuronal Aggregation with a Normal Birthdate-Dependent "Inside-Out" Alignment in the Developing Neocortex

• DOI: 10.1523/jneurosci.0486-10.2010
• 发表时间: 2010-08-18
• 期刊: JOURNAL OF NEUROSCIENCE
• 影响因子: 5.3
• 作者: Kubo, Ken-ichiro;Honda, Takao;Nakajima, Kazunori
• 通讯作者: Nakajima, Kazunori