Mechanisms of the development of neuronal cell community in the central nervous system

我们一直在寻找在发育中的小鼠大脑皮层的脑室下区(SVZ)/多极细胞聚集区(MAZ)调节神经元产生模式的分子。根据功能分析和比较基因组分析的结果，我们确定了一些可能改变SVZ中增殖性神经前体细胞数量的重要候选细胞。我们还发现了可能影响MAZ中多极细胞行为的多个受体和配体。最后，我们证明了多极细胞在MAZ中的行为是由PI(3，4)P2-LamelLipodin-Ena/Vasp-Actin系统控制的。

We have searched for molecules that regulate the patterns of neuronal production in the subventricular zone (SVZ)/multipolar cell accumulation zone (MAZ) of the developing mouse cerebral cortex. As the results of functional assays and comparative genomic analyses, we identified some important candidates that could change the number of proliferative neuronal progenitors in the SVZ. We also have found multiple receptors and ligands that could affect the behavior of multipolar cells in the MAZ. Finally, we show that the behavior of the multipolar cells in the MAZ is controlled through the PI(3,4)P2-Lamellipodin-Ena/VASP-actin system.