Molecular mechanisms of ovarian differentiation induced by sex hormones

性激素诱导卵巢分化的分子机制

• 批准号: 20247004
• 负责人: NAGAHAMA Yoshitaka
• 金额: $ 31.28万
• 依托单位: Ehime University (2011)National Institute for Basic Biology (2008-2010)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20247004/
• 关键词: 卵巣分化; エストロゲン/エストロゲン受容体; R-spondin1; 減数分裂開始; 魚類; 遺伝子ノックダウン(RNAi); C21 steroid; 17α,20β-ジヒドロキシ-4-プレグネン-3-オン(DHP); エストロゲン; エストロゲン受容体; RNAi; tilling; メダカ; 性転換; R-spondinl; C21ステロイド; 7α; 20β-ジヒドロキシ-4-プレグネン-3-オン; Meiosis; Mitosis; ティラピア; チト

Molecular mechanisms of sex hormone-induced ovarian differentiation were investigated in two fishes (medaka and tilapia). Our results show that estrogen (E2) induces ovarian differentiation by acting through estrogen receptors (β2 and β1) and R-spondin1. We also suggest that P450c17-II (a steroidogenic enzyme necessary for the production of DHP, maturation-inducing hormone of fish) is involved in the initiation of meiosis in both XX and XY fish.

以青鳉和罗非鱼为材料，研究了性成熟诱导卵巢分化的分子机制。我们的研究结果表明，雌激素（E2）通过雌激素受体（β2和β1）和R-spondin 1诱导卵巢分化。我们还认为，P450 c17-II（一种类固醇合成酶，用于产生鱼类成熟诱导激素DHP）参与了XX和XY鱼类减数分裂的启动。

项目成果

R-spondin1 is essential for ovarian differentiation in fish

R-spondin1 对于鱼类卵巢分化至关重要

• 发表时间: 2009
• 作者: Zhou;L.Y.;T. Chakraborty;Wang;D.S. and Nagahama;Y
• 通讯作者: Y

Ovarian estrogens are critical for the suppression of male sexual behavior in adult female Japanese medaka, Oryzias latipes

卵巢雌激素对于抑制成年雌性日本青鳉（Oryzias latipes）的雄性性行为至关重要

• 发表时间: 2011
• 作者: Paul-Prasanth;B.;Nagahama;Y.
• 通讯作者: Y.

Endocrine regulation of oogenesis in the medaka, Oryzias latipes. In "Medaka : A Model for Organogenesis, Human Disease and Evolution" (H. Takeda et al. eds.

青鳉、Oryzias latipes 卵子发生的内分泌调节。

• 发表时间: 2011
• 作者: Shibata;N.;Nakamoto;M.;Shibata;Y. and Nagahama;Y.
• 通讯作者: Y.

Sex determination in fishes(Vol.1)("Hormones and Reproduction of Vertebrates")

鱼类的性别决定（第一卷）（“激素与脊椎动物的繁殖”）

• 发表时间: 2011
• 作者: Paul-Prasanth;B.;Nakamura;M.;Nagahama;Y.
• 通讯作者: Y.

Expression of a lyasedeficient Cyp17 in the fish head kidney

裂解酶缺陷型 Cyp17 在鱼头肾中的表达

• 发表时间: 2008
• 作者: Nagahama;Y.
• 通讯作者: Y.