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Molecular mechanisms of ovarian differentiation induced by sex hormones

Molecular mechanisms of ovarian differentiation induced by sex hormones
性激素诱导卵巢分化的分子机制
批准号:
20247004
负责人:
NAGAHAMA Yoshitaka
金额:
$31.28万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2011

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中文摘要
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英文摘要
Molecular mechanisms of sex hormone-induced ovarian differentiation were investigated in two fishes (medaka and tilapia). Our results show that estrogen (E2) induces ovarian differentiation by acting through estrogen receptors (β2 and β1) and R-spondin1. We also suggest that P450c17-II (a steroidogenic enzyme necessary for the production of DHP, maturation-inducing hormone of fish) is involved in the initiation of meiosis in both XX and XY fish.
期刊论文(55)
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会议论文
R-spondin1 is essential for ovarian differentiation in fish
R-spondin1 对于鱼类卵巢分化至关重要
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Zhou, L.Y., T. Chakraborty, Wang, D.S. and Nagahama, Y]
通讯作者: Y
Ovarian estrogens are critical for the suppression of male sexual behavior in adult female Japanese medaka, Oryzias latipes
卵巢雌激素对于抑制成年雌性日本青鳉(Oryzias latipes)的雄性性行为至关重要
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Paul-Prasanth, B., Nagahama, Y.]
通讯作者: Y.
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Shibata, N., Nakamoto, M., Shibata, Y. and Nagahama, Y.]
通讯作者: Y.
Sex determination in fishes(Vol.1)("Hormones and Reproduction of Vertebrates")
鱼类的性别决定(第一卷)(“激素与脊椎动物的繁殖”)
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Paul-Prasanth, B., Nakamura, M., Nagahama, Y.]
通讯作者: Y.
30
    Molecular mechanisms of sexual plasticity in adult medaka gonads
    • 批准号:
      24370028
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.32万
    • 财政年份:
      2012
    • 负责人:
      NAGAHAMA Yoshitaka
    • 依托单位:
    Mechanisms of sex determination and gonadal sex differentiation in fish
    • 批准号:
      16086213
    • 项目类别:
      Grant-in-Aid for Scientific Research on Priority Areas
    • 资助金额:
      $47.87万
    • 财政年份:
      2004
    • 负责人:
      NAGAHAMA Yoshitaka
    • 依托单位:
    Molecular Mechanisms of Sex Change in Fish
    • 批准号:
      16370032
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $9.54万
    • 财政年份:
      2004
    • 负责人:
      NAGAHAMA Yoshitaka
    • 依托单位:
    Functions and Mechanisms of Action of the Medaka Sex-Determining Gene
    海外基金