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Roles of brain K_<ATP> channels in the regulation of energy homeostasis

Roles of brain K_<ATP> channels in the regulation of energy homeostasis
脑 K_<ATP> 通道在能量稳态调节中的作用
批准号:
21890034
负责人:
NAKAMURA Akira
金额:
$1.7万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Research Activity Start-up
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010

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中文摘要
翻译
大脑中的K&lt;ATP&gt;通道参与能量稳态的调节。在本研究中,我们研究了禁食和全身注射葡萄糖对下丘脑神经肽表达的影响。出人意料的是,K_lt;ATP&gt;通道敲除小鼠的神经肽调节与野生型没有不同,这表明大脑K_lt;ATP&gt;通道通过与下丘脑神经肽表达无关的机制来调节能量稳态。
英文摘要
K_<ATP> channels in the brain participate in the regulation of energy homeostasis. In the present study, we examined the changes of neuropeptide expressions in the hypothalamus in response to fasting and systemic glucose administration. Unexpectedly, the regulation of neuropeptides in K_<ATP> channel knockout mice does not differ from that of wild type, suggesting that the brain K_<ATP> channels regulates energy homeostasis through a mechanism other than that involving neuropeptide expression in the hypothalamus.
期刊论文(2)
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科研奖励(0)
会议论文
Sleep state dependence of ventilator long-term facilitation following Acute intermittent hypoxia in Lewis rats.
Lewis 大鼠急性间歇性缺氧后呼吸机长期促进的睡眠状态依赖性。
DOI: --
发表时间: 2010
期刊: Journal of applied physiology
影响因子: 3.3
作者: [Nakamura A., et al.]
通讯作者: et al.
DOI: 10.1152/japplphysiol.90778.2008
发表时间: 2010-08
期刊: Journal of applied physiology
影响因子: 3.3
作者: [A. Nakamura;E. B. Olson;J. Terada;J. Wenninger;G. Bisgard;Gordon S. Mitchell]
通讯作者: A. Nakamura;E. B. Olson;J. Terada;J. Wenninger;G. Bisgard;Gordon S. Mitchell
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  • 批准号:
    15K18840
  • 项目类别:
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  • 资助金额:
    $2.58万
  • 财政年份:
    2015
  • 负责人:
    NAKAMURA Akira
  • 依托单位:
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  • 批准号:
    25650088
  • 项目类别:
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  • 资助金额:
    $2.66万
  • 财政年份:
    2013
  • 负责人:
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  • 依托单位:
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