Roles of brain K_<ATP> channels in the regulation of energy homeostasis

脑 K_<ATP> 通道在能量稳态调节中的作用

• 批准号: 21890034
• 负责人: NAKAMURA Akira
• 金额: $ 1.7万
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21890034/
• 关键词: ATP感受性K^+チャネル; 視床下部; インスリンシグナル; 脳; KATPチャネル; エネルギー

K_<ATP> channels in the brain participate in the regulation of energy homeostasis. In the present study, we examined the changes of neuropeptide expressions in the hypothalamus in response to fasting and systemic glucose administration. Unexpectedly, the regulation of neuropeptides in K_<ATP> channel knockout mice does not differ from that of wild type, suggesting that the brain K_<ATP> channels regulates energy homeostasis through a mechanism other than that involving neuropeptide expression in the hypothalamus.

脑<ATP>内钾通道参与能量稳态的调节。在本研究中，我们研究了下丘脑神经肽表达的变化，响应空腹和全身葡萄糖管理。出乎意料的是，K_通道基因敲除小鼠的神经肽调节<ATP>与野生型小鼠没有差异，这表明脑K_<ATP>通道通过下丘脑神经肽表达以外的机制调节能量稳态。

项目成果

Sleep state dependence of ventilatory long-term facilitation following acute intermittent hypoxia in Lewis rats.

• DOI: 10.1152/japplphysiol.90778.2008
• 发表时间: 2010-08
• 期刊: Journal of applied physiology
• 影响因子: 3.3
• 作者: A. Nakamura;E. B. Olson;J. Terada;J. Wenninger;G. Bisgard;Gordon S. Mitchell

Sleep state dependence of ventilator long-term facilitation following Acute intermittent hypoxia in Lewis rats.

Lewis 大鼠急性间歇性缺氧后呼吸机长期促进的睡眠状态依赖性。

• 发表时间: 2010
• 期刊: Journal of applied physiology
• 影响因子: 3.3
• 作者: Nakamura A.;et al.
• 通讯作者: et al.