Roles of brain K_<ATP> channels in the regulation of energy homeostasis
Roles of brain K_<ATP> channels in the regulation of energy homeostasis
批准号:
21890034
负责人:
NAKAMURA Akira
金额:
$1.7万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Research Activity Start-up
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
脑<ATP>内钾通道参与能量稳态的调节。在本研究中,我们研究了下丘脑神经肽表达的变化,响应空腹和全身葡萄糖管理。出乎意料的是,K_通道基因敲除小鼠的神经肽调节<ATP>与野生型小鼠没有差异,这表明脑K_<ATP>通道通过下丘脑神经肽表达以外的机制调节能量稳态。
英文摘要
K_<ATP> channels in the brain participate in the regulation of energy homeostasis. In the present study, we examined the changes of neuropeptide expressions in the hypothalamus in response to fasting and systemic glucose administration. Unexpectedly, the regulation of neuropeptides in K_<ATP> channel knockout mice does not differ from that of wild type, suggesting that the brain K_<ATP> channels regulates energy homeostasis through a mechanism other than that involving neuropeptide expression in the hypothalamus.
期刊论文(2)
专著(0)
科研奖励(0)
会议论文
DOI:
10.1152/japplphysiol.90778.2008
发表时间:
2010-08
期刊:
Journal of applied physiology
影响因子:
3.3
作者:
[A. Nakamura;E. B. Olson;J. Terada;J. Wenninger;G. Bisgard;Gordon S. Mitchell]
通讯作者:
A. Nakamura;E. B. Olson;J. Terada;J. Wenninger;G. Bisgard;Gordon S. Mitchell
Sleep state dependence of ventilator long-term facilitation following Acute intermittent hypoxia in Lewis rats.
Lewis 大鼠急性间歇性缺氧后呼吸机长期促进的睡眠状态依赖性。
DOI:
--
发表时间:
2010
期刊:
Journal of applied physiology
影响因子:
3.3
作者:
[Nakamura A., et al.]
通讯作者:
et al.
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依托单位:
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依托单位:
Studies on Characteristic Properties of Covalently Bonded Transition Metal Complexes
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依托单位:
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依托单位:
海外基金